"POLR2C" Related Products

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Recombinant Human POLR2C, His-tagged

Cat.No.: POLR2C-231H
Product Overview: POLR2C, 1-275aa, Human, His tag, E.coli
Description: POLR2C is the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. Recombinant human POLR2C protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Source: E.coli
Species: Human
Tag: His-tag
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 1mM DTT, 0.1M NaCl
Molecular Mass: 33.8 kDa (298aa) confirmed by MALDI-TOF
Protein length: 1-275aa
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMPYANQP TVRITELTDE NVKFIIENTD LAVANSIRRV FIAEVPIIAI DWVQIDANSS VLHDEFIAHR LGLIPLISDD IVDKLQYSRD CTCEEFCPEC SVEFTLDVRC NEDQTRHVTS RDLISNSPRV IPVTSRNRDN DPNDYVEQDD ILIVKLRKGQ ELRLRAYAKK GFGKEHAKWN PTAGVAFEYD PDNALRHTVY PKPEEWPKSE YSELDEDESQ APYDPNGKPE RFYYNVESCG SLRPETIVLS ALSGLKKKLS DLQTQLSHEI QSDVLTIN
Purity: >90% by SDS - PAGE
Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration: 0.5 mg/ml (determined by Bradford assay)
Gene Name: POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa [ Homo sapiens ]
Official Symbol: POLR2C
Synonyms: POLR2C; polymerase (RNA) II (DNA directed) polypeptide C, 33kDa; polymerase (RNA) II (DNA directed) polypeptide C (33kD); DNA-directed RNA polymerase II subunit RPB3; RNA polymerase II subunit 3; RPB3; RPB33; RNA polymerase II subunit B3; DNA-directed RNA polymerase II subunit C; DNA-directed RNA polymerase II 33 kDa polypeptide; RPB31; hRPB33; hsRPB3;
Gene ID: 5432
mRNA Refseq: NM_032940
Protein Refseq: NP_116558
MIM: 180663
UniProt ID: P19387
Chromosome Location: 16q13-q21
Pathway: Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystem; DNA Repair, organism-specific biosystem; Disease, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem; Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystem; Formation of HIV-1 elongation complex in the absence of HIV-1 Tat, organism-specific biosystem;
Function: DNA binding; DNA-directed RNA polymerase activity; protein dimerization activity; contributes_to protein kinase activity;

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