Active Recombinant Cynomolgus CD3E, His-tagged, Biotinylated
Cat.No. : | CD3E-274C |
Product Overview : | Biotinylated Recombinant Cynomolgus CD3E Protein(Gln 22 - Asp 117), fused with His tag, was produced in human 293 cells (HEK293). |
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Source : | HEK293 |
Species : | Cynomolgus |
Tag : | His |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. |
Bio-activity : | Immobilize Cynomolgus CD3 epsilon, His Tag at 2 μg/mL, add increasing concentrations of Bispecific T cell Engager (CD3 X BCMA), and then add Biotinylated Human BCMA, Fc,Avitag at 0.2 μg/mL. Detection is performed using HRP-conjugated streptavidin. Binding occurs at a linear range of 1-5 ng/mL. |
Molecular Mass : | The protein has a calculated MW of 16.1 kDa. As a result of glycosylation, the protein migrates as 18-23 kDa under reducing (R) condition, and 33-40 kDa under non-reducing (NR) condition (SDS-PAGE). |
Protein Length : | Gln 22 - Asp 117 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. >90% as determined by SEC-MALS. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Products Types
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CD3E-144M | Recombinant Mouse CD3E Protein, Fc-tagged | +Inquiry |
CD3E-0803H | Recombinant Human CD3E Protein, GST-Tagged | +Inquiry |
CD3E-982R | Recombinant Rhesus CD3E Protein (Met1-Asp117), His-Fc-tagged | +Inquiry |
CD3E-676H | Recombinant Human CD3E Protein, His and C-hFc-tagged | +Inquiry |
◆ Lysates | ||
CD3E-1602CCL | Recombinant Cynomolgus CD3E cell lysate | +Inquiry |
CD3E-1275HCL | Recombinant Human CD3E cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, CD3E levels and T-cell function can be monitored to evaluate the response to cancer immunotherapies like checkpoint inhibitors.
There are currently no approved therapies that directly target CD3E, but it is a target for research in developing immunotherapies and cancer treatments.
There may be ongoing clinical trials using CD3E-targeted therapies in the context of cancer and autoimmune diseases. It's important to check clinical trial databases for specific studies.
Yes, monitoring CD3E levels in HIV-infected individuals can provide valuable information about the progression of the disease and the effectiveness of antiretroviral therapy.
CD3E can be used in research to study T-cell responses in allergic conditions, helping to better understand and diagnose allergies.
Customer Reviews (3)
Write a reviewManufacturers with the capacity for bulk production can offer CD3E protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.
bulk production often leads to economies of scale, making the CD3E protein more cost-effective for research budgets.
Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using CD3E protein.
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