Recombinant Human NEFL, His-tagged
Cat.No. : | NEFL-1255H |
Product Overview : | Recombinant Human NEFL protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | N-term-352aa |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | NEFL neurofilament, light polypeptide [ Homo sapiens ] |
Official Symbol : | NEFL |
Synonyms : | NEFL; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament light polypeptide; CMT1F; CMT2E; NF68; NFL; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament protein, light chain; light molecular weight neurofilament protein; NF-L; FLJ53642; |
Gene ID : | 4747 |
mRNA Refseq : | NM_006158 |
Protein Refseq : | NP_006149 |
MIM : | 162280 |
UniProt ID : | P07196 |
Chromosome Location : | 8p21.2 |
Pathway : | Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; CREB phosphorylation through the activation of CaMKII, organism-specific biosystem; CREB phosphorylation through the activation of Ras, organism-specific biosystem; Neuronal System, organism-specific biosystem; Neurotransmitter Receptor Binding And Downstream Transmission In ThePostsynaptic Cell, organism-specific biosystem; |
Function : | identical protein binding; protein C-terminus binding; protein binding; structural constituent of cytoskeleton; |
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◆ Native Protein | ||
NEFL-181B | Native bovine NEFL | +Inquiry |
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◆ Lysates | ||
NEFL-3884HCL | Recombinant Human NEFL 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionNEFL is the light chain subunit of neurofilaments, crucial for their assembly and function.
It is a major component of neurofilaments, providing stability and support to axons.
Genetic mutations in NEFL have been linked to Charcot-Marie-Tooth disease and other neuropathies.
NEFL plays a crucial role in maintaining the structure and function of neuronal axons.
NEFL is predominantly expressed in neurons, particularly in the axons.
Therapeutic strategies are being developed to target NEFL aggregation and dysfunction in neurodegenerative diseases.
Abnormal accumulation of NEFL is associated with various neurodegenerative diseases.
Customer Reviews (3)
Write a reviewWorked well, fast shipping.
Satisfied with the quality.
Excellent product, very satisfied.
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