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Recombinant Human RNF168, GST-tagged

Cat.No. : RNF168-2338H
Product Overview : Recombinant Human RNF168 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Source : E.coli
Species : Human
Tag : GST
Protein length : C-351aa
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : RNF168 ring finger protein 168, E3 ubiquitin protein ligase [ Homo sapiens ]
Official Symbol : RNF168
Synonyms : RNF168; ring finger protein 168, E3 ubiquitin protein ligase; ring finger protein 168; E3 ubiquitin-protein ligase RNF168; FLJ35794; FLJ39749;
Gene ID : 165918
mRNA Refseq : NM_152617
Protein Refseq : NP_689830
MIM : 612688
UniProt ID : Q8IYW5
Chromosome Location : 3q29
Function : chromatin binding; histone binding; ligase activity; metal ion binding; protein binding; ubiquitin binding; ubiquitin-protein ligase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any current clinical trials involving RNF168 protein? 08/29/2021

Clinical trials investigating the potential use of RNF168 as a target for cancer therapy or as a biomarker for cancer prognosis may be underway, but specific details would need to be checked.

How does RNF168 protein contribute to the DNA damage response? 08/21/2021

RNF168 plays a role in initiating a signaling cascade that leads to the recruitment of other DNA repair proteins to the site of DNA damage, promoting repair and maintaining genomic stability.

How does RNF168 protein interact with other proteins in the DNA repair pathway? 06/29/2021

RNF168 interacts with various proteins involved in the DNA damage response, such as 53BP1 and BRCA1, to coordinate the repair of DNA lesions and maintain genomic stability.

Can mutations in the RNF168 gene be inherited and lead to an increased risk of cancer? 01/05/2021

Yes, inherited mutations in the RNF168 gene can increase the risk of developing certain cancers, particularly those associated with DNA damage and repair deficiencies.

Are there any known side effects or toxicities associated with modulating RNF168 activity in cancer therapy? 04/19/2017

The potential side effects and toxicities of targeting RNF168 in cancer therapy are still being explored, and would depend on the specific approach and modality used.

Customer Reviews (3)

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Reviews
10/04/2020

    Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.

    09/03/2017

      This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.

      06/19/2017

        the RNF168 protein offers numerous advantages in trials and research experiments.

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