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Recombinant Human POLK, His-tagged

Cat.No. : POLK-838H
Product Overview : Recombinant Human POLK, fused with His tag C-Terminus, was expressed in E. coli.
  • Specification
  • Gene Information
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Description : External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass.
Source : E. coli
Species : Human
Tag : His
Form : Liquid
Molecular Mass : 64 kDa
Protein length : 1 to 560
AA Sequence : MDSTKEKCDSYKDDLLLRMGLNDNK AGMEGLDKEKINKIIMEATKGSRFY GNELKKEKQVNQRIENMMQQKAQIT SQQLRKAQLQVDRFAMELEQSRNLS NTIVHIDMDAFYAAVEMRDNPELKD KPIAVGSMSMLSTSNYHARRFGVRA AMPGFIAKRLCPQLIIVPPNFDKYR AVSKEVKEILADYDPNFMAMSLDEA YLNITKHLEERQNWPEDKRRYFIKM GSSVENDNPGKEVNKLSEHERSISP LLFEESPSDVQPPGDPFQVNFEEQN NPQILQNSVVFGTSAQEVVKEIRFR IEQKTTLTASAGIAPNTMLAKVCSD KNKPNGQYQILPNRQAVMDFIKDLP IRKVSGIGKVTEKMLKALGIITCTE LYQQRALLSLLFSETSWHYFLHISL GLGSTHLTRDGERKSMSVERTFSEI NKAEEQYSLCQELCSELAQDLQKER LKGRTVTIKLKNVNFEVKTRASTVS SVVSTAEEIFAIAKELLKTEIDADF PHPLRLRLMGVRISSFPNEEDRKHQ QRSIIGFLQAGNQALSATECTLEKT DKDKFVKPLE
Purity : >90% by SDS-PAGE.
Applications : ELISA; SDS-PAGE; Western blot; Functional Studies
Storage : Store at -20°C or -80°C.
Concentration : 3.2 mg/ml
Gene Name : POLK?polymerase (DNA directed) kappa [?Homo sapiens?(human) ]
Official Symbol : POLK
Synonyms : POLK; DINP; POLQ; DINB1; polymerase (DNA directed) kappa; DNA polymerase kappa; NP_057302.1; EC 2.7.7.7
Gene ID : 51426
mRNA Refseq : NM_016218
Protein Refseq : NP_057302
MIM : 605650
UniProt ID : Q9UBT6
Chromosome Location : 5q13
Pathway : Fanconi anemia pathway
Function : DNA-directed DNA polymerase activity; damaged DNA binding; metal ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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