Recombinant Human IL22, StrepII-tagged
Cat.No. : | IL22-215H |
Product Overview : | Purified, full-length human recombinant Interleukin 22 or IL22 protein (amino acids 34-179, 146 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 16.7 kDa. (Accession NP_065386.1; UniProt Q9GZX6) |
- Specification
- Gene Information
- Related Products
Description : | IL22 acts primarily on epithelial cells and is involved in inflammatory response. The cytokine induces multiple signaling pathways that help prevent tissue damage during inflammation. IL22 levels are often up-regulated in many chronic inflammatory conditions. This protein is a member of IL10 family. |
Source : | Human Cells |
Species : | Human |
Tag : | StrepII |
Form : | Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free). |
Protein length : | 34-179, 146 a.a. |
AA Sequence : | APISSHCRLDKSNFQQPYITNRTFM LAKEASLADNNTDVRLIGEKLFHGV SMSERCYLMKQVLNFTLEEVLFPQS DRFQPYMQEVVPFLARLSNRLSTCH IEGDDLHIQRNVQKLKDTVKKLGES GEIKAIGELDLLFMSLRNACI |
Endotoxin : | <0.1 eu per ug protein by lal |
Purity : | >95% pure by SDS-PAGE |
Storage : | 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles. |
Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. |
Gene Name : | IL22 interleukin 22 [ Homo sapiens ] |
Official Symbol : | IL22 |
Synonyms : | IL22; interleukin 22; interleukin-22; IL 10 related T cell derived inducible factor; IL 21; IL 22; IL D110; IL TIF; ILTIF; MGC79382; MGC79384; TIFa; TIFIL 23; zcyto18; cytokine Zcyto18; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL-22; IL-TIF; IL-D110; TIFIL-23; |
Gene ID : | 50616 |
mRNA Refseq : | NM_020525 |
Protein Refseq : | NP_065386 |
MIM : | 605330 |
UniProt ID : | Q9GZX6 |
Chromosome Location : | 12q15 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; |
Function : | cytokine activity; interleukin-22 receptor binding; |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (10)
Ask a questionIL22 enhances gut epithelial repair mechanisms.
IL22 activates STAT3 to modulate downstream targets.
IL22 interacts synergistically with IL-17 during inflammation.
IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.
IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.
IL22 expression is upregulated in psoriasis.
IL22 expression is upregulated during viral infections like Hepatitis C.
IL22 contributes to anti-tumor immunity by activating NK cells.
IL22 promotes Th22 cell differentiation.
IL22 polymorphisms affect its binding affinity and signaling.
Customer Reviews (3)
Write a reviewHigh specificity.
Good for Th17 differentiation.
Effective in gut repair assays.
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