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Recombinant Human LTA, StrepII-tagged

Cat.No. : LTA-221H
Product Overview : Purified, full-length human recombinant Lymphotoxin-alpha LTA (TNFb) protein (amino acids 35-205, 171 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 19.4 kDa. (Accession NP_00116.2; UniProt P01374)
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Description : LTA is a cytokine that, in its homotrimeric form, binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form, it binds with LTB to TNFRSF3/LTBR. Lymphotoxins are produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
Source : Human Cells
Species : Human
Tag : StrepII
Form : Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free).
Protein length : 35-205, 171 a.a.
AA Sequence : LPGVGLTPSAAQTARQHPKMHLAHS TLKPAAHLIGDPSKQNSLLWRANTD RAFLQDGFSLSNNSLLVPTSGIYFV YSQVVFSGKAYSPKATSSPLYLAHE VQLFSSQYPFHVPLLSSQKMVYPGL QEPWLHSMYHGAAFQLTQGDQLSTH TDGIPHLVLSPSTVFFGAFAL
Endotoxin : <0.1 eu per ug protein by lal
Purity : >95% pure by SDS-PAGE
Storage : 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles.
Reconstitution : Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml.
Gene Name : LTA lymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ]
Official Symbol : LTA
Synonyms : LTA; lymphotoxin alpha (TNF superfamily, member 1); TNFB; lymphotoxin-alpha; LT; TNFSF1; LT-alpha; TNF-beta; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1;
Gene ID : 4049
mRNA Refseq : NM_000595
Protein Refseq : NP_000586
MIM : 153440
UniProt ID : P01374
Chromosome Location : 6p21.3
Pathway : Apoptosis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem;
Function : cytokine activity; receptor binding; tumor necrosis factor receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are some potential therapeutic applications of LTA protein? 02/21/2023

LTA protein is being investigated for its potential use in cancer therapy, autoimmune diseases, and infectious diseases.

Are there any clinical trials involving LTA protein? 06/22/2022

Clinical trials may have been initiated to investigate the therapeutic potential of LTA protein since my last update. It's advisable to check the latest information.

What are some potential side effects or adverse reactions associated with LTA protein therapy? 03/19/2021

Potential side effects may include immune-related adverse events, such as inflammation and cytokine release syndrome.

Can LTA protein be used to treat autoimmune diseases? 08/11/2018

LTA protein has been studied for its potential to modulate autoimmune responses, but more research is needed.

Can LTA protein be used in cancer treatment? 04/05/2017

LTA protein has shown potential in cancer immunotherapy by targeting and destroying cancer cells.

Customer Reviews (3)

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Reviews
04/14/2020

    Its purity, integrity, and functionality are ensured through stringent quality control measures, which instills confidence in the reliability and accuracy of my research results.

    01/03/2020

      Their technical expertise, product quality, customer support, and supply management collectively contribute to the success and progress of my trials.

      08/24/2017

        The manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.

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