Recombinant Human LTA, StrepII-tagged
Cat.No. : | LTA-221H |
Product Overview : | Purified, full-length human recombinant Lymphotoxin-alpha LTA (TNFb) protein (amino acids 35-205, 171 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 19.4 kDa. (Accession NP_00116.2; UniProt P01374) |
- Specification
- Gene Information
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Description : | LTA is a cytokine that, in its homotrimeric form, binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form, it binds with LTB to TNFRSF3/LTBR. Lymphotoxins are produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. |
Source : | Human Cells |
Species : | Human |
Tag : | StrepII |
Form : | Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free). |
Protein length : | 35-205, 171 a.a. |
AA Sequence : | LPGVGLTPSAAQTARQHPKMHLAHS TLKPAAHLIGDPSKQNSLLWRANTD RAFLQDGFSLSNNSLLVPTSGIYFV YSQVVFSGKAYSPKATSSPLYLAHE VQLFSSQYPFHVPLLSSQKMVYPGL QEPWLHSMYHGAAFQLTQGDQLSTH TDGIPHLVLSPSTVFFGAFAL |
Endotoxin : | <0.1 eu per ug protein by lal |
Purity : | >95% pure by SDS-PAGE |
Storage : | 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles. |
Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. |
Gene Name : | LTA lymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ] |
Official Symbol : | LTA |
Synonyms : | LTA; lymphotoxin alpha (TNF superfamily, member 1); TNFB; lymphotoxin-alpha; LT; TNFSF1; LT-alpha; TNF-beta; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1; |
Gene ID : | 4049 |
mRNA Refseq : | NM_000595 |
Protein Refseq : | NP_000586 |
MIM : | 153440 |
UniProt ID : | P01374 |
Chromosome Location : | 6p21.3 |
Pathway : | Apoptosis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; |
Function : | cytokine activity; receptor binding; tumor necrosis factor receptor binding; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionLTA protein is being investigated for its potential use in cancer therapy, autoimmune diseases, and infectious diseases.
Clinical trials may have been initiated to investigate the therapeutic potential of LTA protein since my last update. It's advisable to check the latest information.
Potential side effects may include immune-related adverse events, such as inflammation and cytokine release syndrome.
LTA protein has been studied for its potential to modulate autoimmune responses, but more research is needed.
LTA protein has shown potential in cancer immunotherapy by targeting and destroying cancer cells.
Customer Reviews (3)
Write a reviewIts purity, integrity, and functionality are ensured through stringent quality control measures, which instills confidence in the reliability and accuracy of my research results.
Their technical expertise, product quality, customer support, and supply management collectively contribute to the success and progress of my trials.
The manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.
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