| Description : |
Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids, and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. The protein belongs to the ALB/AFP/VDB family and contains 3 albumin domains. |
| Source : |
Human Cells |
| Species : |
Human |
| Tag : |
StrepII |
| Form : |
Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free). |
| Protein length : |
20-609, 590 a.a. |
| AA Sequence : |
TLHRNEYGIASILDSYQCTAEISLA DLATIFFAQFVQEATYKEVSKMVKD ALTAIEKPTGDEQSSGCLENQLPAF LEELCHEKEILEKYGHSDCCSQSEE GRHNCFLAHKKPTPASIPLFQVPEP VTSCEAYEEDRETFMNKFIYEIARR HPFLYAPTILLWAARYDKIIPSCCK AENAVECFQTKAATVTKELRESSLL NQHACAVMKNFGTRTFQAITVTKLS QKFTKVNFTEIQKLVLDVAHVHEHC CRGDVLDCLQDGEKIMSYICSQQDT LSNKITECCKLTTLERGQCIIHAEN DEKPEGLSPNLNRFLGDRDFNQFSS GEKNIFLASFVHEYSRRHPQLAVSV ILRVAKGYQELLEKCFQTENPLECQ DKGEEELQKYIQESQALAKRSCGLF QKLGEYYLQNAFLVAYTKKAPQLTS SELMAITRKMAATAATCCQLSEDKL LACGEGAADIIIGHLCIRHEMTPVN PGVGQCCTSSYANRRPCFSSLVVDE TYVPPAFSDDKFIFHKDLCQAQGVA LQTMKQEFLINLVKQKPQITEEQLE AVIADFSGLLEKCCQGQEQEVCFAE EGQKLISKTRAALGV |
| Endotoxin : |
<0.1 eu per ug protein by lal |
| Purity : |
>95% pure by SDS-PAGE |
| Storage : |
12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles. |
| Reconstitution : |
Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. |
