Recombinant Human MLH1, StrepII-tagged
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Cat.No. : | MLH1-233H |
Product Overview : | Purified human recombinant DNA mismatch repair MLH1 protein (amino acids 410-652, 243 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 27.4 kDa. (Accession NP_000240.1; UniProt P40692) |
Description : | This product is a fragment of MLH1, which is a component of the post-replicative DNA mismatch repair system (MMR). It is a human homolog of the E. coli DNA mismatch repair gene mutL. Native MLH1 heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis. |
Source : | Human Cells |
Species : | Human |
Tag : | StrepII |
Form : | Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free). |
Protein length : | 410-652, 243 a.a. |
AA Sequence : | AIVTEDKTDI SSGRARQQDE EMLELPAPAE VAAKNQSLEG DTTKGTSEMS EKRGPTSSNP RKRHREDSDV EMVEDDSRKE MTAACTPRRR IINLTSVLSL QEEINEQGHE VLREMLHNHS FVGCVNPQWA LAQHQTKLYL LNTTKLSEEL FYQILIYDFA NFGVLRLSEP APLFDLAMLA LDSPESGWTE EDGPKEGLAE YIVEFLKKKA EMLADYFSLE IDEEGNLIGL PLLIDNYVPP LEG |
Endotoxin : | <0.1 eu per ug protein by lal |
Purity : | >95% pure by SDS-PAGE |
Storage : | 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles. |
Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. |
Gene Name : | MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [ Homo sapiens ] |
Official Symbol : | MLH1 |
Synonyms : | MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); COCA2, mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2); DNA mismatch repair protein Mlh1; FCC2; HNPCC; HNPCC2; COCA2; hMLH1; MGC5172; |
Gene ID : | 4292 |
mRNA Refseq : | NM_000249 |
Protein Refseq : | NP_000240 |
MIM : | 120436 |
UniProt ID : | P40692 |
Chromosome Location : | 3p22.3 |
Pathway : | BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Endometrial cancer, organism-specific biosystem; Endometrial cancer, conserved biosystem; Fanconi anemia pathway, organism-specific biosystem; |
Function : | ATP binding; ATPase activity; contributes_to MutSalpha complex binding; guanine/thymine mispair binding; mismatched DNA binding; protein binding; contributes_to protein binding; contributes_to single-stranded DNA binding; |
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