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Recombinant Human MME, StrepII-tagged

Cat.No. : MME-236H
Product Overview : Purified human recombinant NeprilysinCD10 or Neprilysin protein (amino acids 55-750, 696 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 79.4 kDa. (Accession NP_000893.2; UniProt P08473)
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Description : This product is the extracellular domain of CD10. CD10 is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
Source : Human Cells
Species : Human
Tag : StrepII
Form : Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free).
Protein length : 55-750, 696 a.a.
AA Sequence : GICKSSDCIKSAARLIQNMDATTEP CTDFFKYACGGWLKRNVIPETSSRY GNFDILRDELEVVLKDVLQEPKTED IVAVQKAKALYRSCINESAIDSRGG EPLLKLLPDIYGWPVATENWEQKYG ASWTAEKAIAQLNSKYGKKVLINLF VGTDDKNSVNHVIHIDQPRLGLPSR DYYECTGIYKEACTAYVDFMISVAR LIRQEERLPIDENQLALEMNKVMEL EKEIANATAKPEDRNDPMLLYNKMT LAQIQNNFSLEINGKPFSWLNFTNE IMSTVNISITNEEDVVVYAPEYLTK LKPILTKYSARDLQNLMSWRFIMDL VSSLSRTYKESRNAFRKALYGTTSE TATWRRCANYVNGNMENAVGRLYVE AAFAGESKHVVEDLIAQIREVFIQT LDDLTWMDAETKKRAEEKALAIKER IGYPDDIVSNDNKLNNEYLELNYKE DEYFENIIQNLKFSQSKQLKKLREK VDKDEWISGAAVVNAFYSSGRNQIV FPAGILQPPFFSAQQSNSLNYGGIG MVIGHEITHGFDDNGRNFNKDGDLV DWWTQQSASNFKEQSQCMVYQYGNF SWDLAGGQHLNGINTLGENIADNGG LGQAYRAYQNYIKKNGEEKLLPGLD LNHKQLFFLNFAQVWCGTYRPEYAV NSIKTDVHSPGNFRIIGTLQNSAEF SEAFHCRKNSYMNPEKKCRVW
Endotoxin : <0.1 eu per ug protein by lal
Purity : ~90% pure by SDS-PAGE
Storage : 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles.
Reconstitution : Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml.
Gene Name : MME membrane metallo-endopeptidase [ Homo sapiens ]
Official Symbol : MME
Synonyms : MME; membrane metallo-endopeptidase; neprilysin; CALLA; CD10; enkephalinase; NEP; neutral endopeptidase; atriopeptidase; skin fibroblast elastase; neutral endopeptidase 24.11; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); SFE; MGC126681; MGC126707; DKFZp686O16152;
Gene ID : 4311
mRNA Refseq : NM_000902
Protein Refseq : NP_000893
MIM : 120520
UniProt ID : P08473
Chromosome Location : 3q25.2
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem; Renin-angiotensin system, organism-specific biosystem;
Function : endopeptidase activity; endopeptidase activity; metal ion binding; metalloendopeptidase activity; metalloendopeptidase activity; peptidase activity; peptide binding; protein binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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