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Recombinant Human EPO, StrepII-tagged

Cat.No. : EPO-252H
Product Overview : Purified, full-length human recombinant EPO or Erythropoietin protein (amino acids 28-193, 166 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 18.4 kDa. (Accession NP_000790.2; UniProt P01588)
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Description : Erythropoietin (EPO) is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Source : Human Cells
Species : Human
Tag : StrepII
Form : Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free).
Protein length : 28-193, 166 a.a.
AA Sequence : APPRLICDSRVLERYLLEAKEAENI TTGCAEHCSLNENITVPDTKVNFYA WKRMEVGQQAVEVWQGLALLSEAVL RGQALLVNSSQPWEPLQLHV DKAVSGLRSLTTLLRALGAQKEAIS PPDAASAAPLRTITADTFRKLFRVY SNFLRGKLKLYTGEACRTGDR
Endotoxin : <0.1 eu per ug protein by lal
Purity : >80% pure by SDS-PAGE
Storage : 12 months at -20°C as supplied; 1 month at °C after reconstitution. Avoid freeze/thaw cycles.
Reconstitution : Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml.
Gene Name : EPO erythropoietin [ Homo sapiens ]
Official Symbol : EPO
Synonyms : EPO; erythropoietin; EP; epoetin; MVCD2; MGC138142;
Gene ID : 2056
mRNA Refseq : NM_000799
Protein Refseq : NP_000790
MIM : 133170
UniProt ID : P01588
Chromosome Location : 7q21
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; EPO Receptor Signaling, organism-specific biosystem; EPO signaling pathway, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem;
Function : erythropoietin receptor binding; eukaryotic cell surface binding; hormone activity; protein binding; protein kinase activator activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the relationship between EPO protein and cardiovascular disease? 08/05/2019

EPO protein can promote the renewal and repair of heart blood vessels, and has the effect of protecting the heart from ischemia-reperfusion damage.

How does EPO protein regulate erythropoiesis? 07/12/2019

By binding to receptors, EPO proteins activate signaling pathways that promote the proliferation and differentiation of hematopoietic stem cells in bone marrow into erythrocytes.

How about the clinical use of EPO protein? 06/12/2019

EPO protein can be used by injection or oral, and the specific method and dosage need to be determined according to the condition and the doctor's advice.

What are the implications of EPO protein research for the future of treating anemia? 05/14/2019

The study of EPO protein helps to understand the regulatory mechanism of erythropoiesis and provides new ideas and methods for the treatment of anemia, such as developing more effective EPO protein analogues or improving existing treatment regimens.

How is EPO protein treated for anemia? 05/02/2019

This protein stimulates the bone marrow to produce more red blood cells, thereby increasing hemoglobin levels and treating anemia.

What is the role of EPO protein in kidney disease? 04/04/2019

In kidney disease, due to impaired kidney function, the production of EPO protein decreases, leading to anemia. Supplementation with exogenous EPO protein can help correct anemia caused by kidney problems.

Customer Reviews (3)

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Reviews
12/28/2021

    Stability is truly remarkable, can maintain its activity even under extreme conditions.

    08/31/2021

      Can catalyze reactions even under extreme conditions.

      02/03/2019

        This protein's repeatability is truly exceptional, consistently delivering reliable results even under challenging conditions.

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