Recombinant Human CDH1, StrepII-tagged
Cat.No. : | CDH1-278H |
Product Overview : | Purified human recombinant CDH1 (CADH1) protein (amino acids 731-882, 152 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 17.1 kDa. (Accession NP_004351.1; UniProt P12830) |
- Specification
- Gene Information
- Related Products
Description : | This product is the intracellular domain of CDH1. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. CDH1 is a homodimer comprised of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancer. |
Source : | Human Cells |
Species : | Human |
Tag : | StrepII |
Form : | Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free) |
Protein length : | 731-882, 152 a.a. |
AA Sequence : | LRRRAVVKEPLLPPEDDTRDNVYYY DEEGGGEEDQDFDLSQLHRGLDARP EVTRNDVAPTLMSVPRYLPRPANPD EIGNFIDENLKAADTDPTAPPYDSL LVFDYEGSGSEAASLSSLNSSESDK DQDYDYLNEWGNRFKKLADMYGGGE DD |
Endotoxin : | <0.1 eu per μg protein by lal |
Purity : | >90% by SDS-PAGE |
Storage : | 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles |
Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for up to 1 month |
Gene Name : | CDH1 cadherin 1, type 1, E-cadherin (epithelial) [ Homo sapiens ] |
Official Symbol : | CDH1 |
Synonyms : | CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; cadherin-1; CD324; E Cadherin; uvomorulin; CAM 120/80; E-Cadherin; cell-CAM 120/80; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; CDHE; ECAD; LCAM; Arc-1; |
Gene ID : | 999 |
mRNA Refseq : | NM_004360 |
Protein Refseq : | NP_004351 |
MIM : | 192090 |
UniProt ID : | P12830 |
Chromosome Location : | 16q22.1 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Adherens junctions interactions, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cell adhesionproteins, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; |
Function : | GTPase activating protein binding; calcium ion binding; cell adhesion molecule binding; gamma-catenin binding; protein binding; |
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CDH1-2645H | Recombinant Human CDH1 protein(791-880 aa), C-His-tagged | +Inquiry |
Cdh1-1719M | Active Recombinant Mouse Cdh1 Protein | +Inquiry |
CDH1-208H | Recombinant Human CDH1 Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
CDH1-938HCL | Recombinant Human CDH1 cell lysate | +Inquiry |
CDH1-1892MCL | Recombinant Mouse CDH1 cell lysate | +Inquiry |
CDH1-736RCL | Recombinant Rat CDH1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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