Cat.No. :	IL4-279H
Product Overview :	Purified, full-length human recombinant IL4 protein (amino acids 25-153, 129 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 17.5 kDa. (Accession NP_000580; UniProt P05112)
Description :	IL4 is a pleiotropic cytokine produced by activated T cells. It participates in several B-cell activation processes as well as of other cell types. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1, as well as regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. In addition, it is a costimulator of DNA-synthesis.
Source :	Human Cells
Species :	Human
Tag :	StrepII
Form :	Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free)
Protein length :	25-153, 129 a.a.
AA Sequence :	HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHR HKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
Endotoxin :	<0.1 eu per μg protein by lal
Purity :	>85% by SDS-PAGE
Storage :	12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles
Reconstitution :	Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml

Gene Name :	IL4 interleukin 4 [ Homo sapiens ]
Official Symbol :	IL4
Synonyms :	IL4; interleukin 4; interleukin-4; B cell growth factor 1; B_cell stimulatory factor 1; BCGF 1; BCGF1; BSF1; IL 4; lymphocyte stimulatory factor 1; MGC79402; binetrakin; pitrakinra; IL-4; BSF-1; BCGF-1;
Gene ID :	3565
mRNA Refseq :	NM_000589
Protein Refseq :	NP_000580
MIM :	147780
UniProt ID :	P05112
Chromosome Location :	5q23-q31
Pathway :	Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD40/CD40L signaling, organism-specific biosystem;
Function :	cytokine activity; growth factor activity; interleukin-4 receptor binding; protein binding;

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