Recombinant Human LTB, StrepII-tagged

• Cat.No.: LTB-285H
• Product Overview: Purified human recombinant TNF-C protein (amino acids 49-244, 196 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 25.4 kDa. (Accession NP_002332; UniProt Q06643)

Specification

• Description: Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue.
• Source: Human Cells
• Species: Human
• Tag: StrepII
• Form: Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free)
• Protein length: 49-244, 196 a.a.
• AA Sequence: QDQGGLVTETADPGAQAQQGLGFQK LPEEEPETDLSPGLPAAHLIGAPLK GQGLGWETTKEQAFLTSGTQFSDAE GLALPQDGLYYLYCLVGYRGRAPPG GGDPQGRSVTLRSSLYRAGGAYGPG TPELLLEGAETVTPVLDPARRQGYG PLWYTSVGFGGLVQLRRGERVYVNI SHPDMVDFARGKTFFGAVMVG
• Endotoxin: <0.1 eu per μg protein by lal
• Purity: >60% by SDS-PAGE
• Storage: 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles.
• Reconstitution: Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for up to 1 month.

Gene Information

• Gene Name: LTB lymphotoxin beta (TNF superfamily, member 3) [ Homo sapiens ]
• Official Symbol: LTB
• Synonyms: LTB; lymphotoxin beta (TNF superfamily, member 3); TNFC; lymphotoxin-beta; p33; TNFSF3; TNF-C; LT-beta; tumor necrosis factor C; tumor necrosis factor ligand superfamily member 3
• Gene ID: 4050
• mRNA Refseq: NM_002341
• Protein Refseq: NP_002332
• MIM: 600978
• UniProt ID: Q06643
• Chromosome Location: 6p21.3
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem
• Function: cytokine activity; receptor binding; tumor necrosis factor receptor binding