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Recombinant Human STAT3, GST-tagged

Cat.No.: STAT3-39228H
Product Overview: Recombinant Human STAT3 was expressed as gst-tagged fusion protein by E.Coli and puri?ed by GSH-sepharose.
Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Source: E.coli
Species: Human
Tag: GST
Protein length: False
AA Sequence: 2-219aa
Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) [ Homo sapiens (human) ]
Official Symbol: STAT3
Synonyms: STAT3; APRF; HIES; signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer and activator of transcription 3; DNA-binding protein APRF; acute-phase response factor
Gene ID: 6774
mRNA Refseq: NM_003150
Protein Refseq: NP_003141
MIM: 102582
UniProt ID: P40763
Chromosome Location: 17q21.31
Pathway: AGE/RAGE pathway; Acute myeloid leukemia; B Cell Receptor Signaling Pathway
Function: CCR5 chemokine receptor binding; RNA polymerase II repressing transcription factor binding; glucocorticoid receptor binding

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