Recombinant Human TGFBR1 (T204D), GST-tagged
Cat.No. : | TGFBR1-39H |
Product Overview : | Recombinant human TGFBR1 (T204D) (80-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | TGFBR1 or transforming growth factor, beta-receptor 1 is a member of the TGFbeta receptor subfamily and is a ser/thr protein kinase that forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. Mutations in TGFBR1gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR1-dependent signaling is required for angiogenesis but not for the development of hematopoietic progenitor cells and functional hematopoiesis. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~66 kDa |
Applications : | Kinase Assay |
Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | TGFBR1 transforming growth factor, beta receptor 1 [ Homo sapiens ] |
Official Symbol : | TGFBR1 |
Synonyms : | TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5; tbetaR-I; TGF-beta receptor type I; TGF-beta type I receptor; activin receptor-like kinase 5; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; transforming growth factor-beta receptor type I; activin A receptor type II-like protein kinase of 53kD; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); AAT5; ALK5; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; |
Gene ID : | 7046 |
mRNA Refseq : | NM_001130916 |
Protein Refseq : | NP_001124388 |
MIM : | 190181 |
UniProt ID : | P36897 |
Chromosome Location : | 9q22 |
Pathway : | ALK1 signaling events, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; |
Function : | ATP binding; I-SMAD binding; SMAD binding; SMAD binding; contributes_to growth factor binding; metal ion binding; nucleotide binding; protein binding; protein heterodimerization activity; protein serine/threonine kinase activity; receptor activity; transforming growth factor beta binding; contributes_to transforming growth factor beta binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; transforming growth factor beta-activated receptor activity; transforming growth factor beta-activated receptor activity; transforming growth factor beta-activated receptor activity; contributes_to transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity; type II transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding; ubiquitin protein ligase binding; |
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◆ Lysates | ||
TGFBR1-2482HCL | Recombinant Human TGFBR1 cell lysate | +Inquiry |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIn-depth study of the signaling pathways and regulatory mechanisms of TGFBR1 can provide important clues for the development of therapeutic strategies for related diseases.
Gene polymorphisms in TGFBR1 may be associated with susceptibility to some diseases, such as heart disease and diabetes.
Yes, TGFBR1 regulates the proliferation and differentiation of osteocytes in the skeletal system and has been implicated in diseases of the skeletal system.
The TGFBR1 pathway is involved in a variety of pathological processes in liver diseases, such as fibrosis and the occurrence of liver cancer.
Some inhibitors of TGFBR1 have been developed, such as LY2157299 and SD-208.
TGFBR1 may play a role in regulating glomerular injury, fibrosis and renal failure in kidney disease.
Customer Reviews (3)
Write a reviewEasy to purify and high purity in production.
The protein has strong reducibility.
He did well in the ELISA test.
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