Recombinant Human nucleic acid binding protein 1, His-tagged
Cat.No. : | NABP1-270H |
Product Overview : | NABP1, 1-204aa, Human, His tag, E.coli |
- Specification
- Gene Information
- Related Products
Description : | Nucleic acid binding protein 1, also known as NABP1, is component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, the protein acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. This protein is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Recombinant human NABP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Source : | E.coli |
Species : | Human |
Tag : | His-tag |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT |
Molecular Mass : | 24.8 kDa (227aa) confirmed by MALDI-TOF |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSMNRVNDP LIFIRDIKPG LKNLNVVFIV LEIGRVTKTK DGHEVRSCKV ADKTGSITIS VWDEIGGLIQ PGDIIRLTRG YASMWKGCLT LYTGRGGELQ KIGEFCMVYS EVPNFSEPNP DYRGQQNKGA QSEQKNNSMN SNMGTGTFGP VGNGVHTGPE SREHQFSHAG RSNGRGLINP QLQGTASNQT VMTTISNGRD PRRAFKR |
Purity : | >95% by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5mg/ml (determined by Bradford assay) |
Gene Name : | NABP1 nucleic acid binding protein 1 [ Homo sapiens (human) ] |
Official Symbol : | NABP1 |
Synonyms : | NABP1; SSB2; OBFC2A; SOSS-B2; nucleic acid binding protein 1; SOSS complex subunit B2; sensor of ssDNA subunit B2; nucleic acid-binding protein 1; single-stranded DNA-binding protein 2; sensor of single-strand DNA complex subunit B2; oligonucleotide/oligosaccharide-binding fold containing 2A; oligonucleotide/oligosaccharide-binding fold-containing protein 2A |
Gene ID : | 64859 |
mRNA Refseq : | NM_001031716 |
Protein Refseq : | NP_001026886 |
MIM : | 612103 |
UniProt ID : | Q96AH0 |
Chromosome Location : | 2q32.3 |
Function : | RNA binding; single-stranded DNA binding |
Products Types
◆ Recombinant Protein | ||
NABP1-3574H | Recombinant Human NABP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
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NABP1-3543R | Recombinant Rat NABP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NABP1-1123H | Recombinant Human NABP1 | +Inquiry |
NABP1-4718H | Recombinant Human NABP1 protein, His-SUMO-tagged | +Inquiry |
◆ Lysates | ||
NABP1-451HCL | Recombinant Human NABP1 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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