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Recombinant Human troponin I type 2 (skeletal, fast), His-tagged

Cat.No.: TNNI2-371H
Product Overview: TNNI2, 1-182aa, Human, His tag, E.coli
Description: Troponin I, fast skeletal muscle, also known as TNNI2, is a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in TNNI2 cause myopathy and distal arthrogryposis type 2B. Recombinant human TNNI2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Source: E.coli
Species: Human
Tag: His-tag
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2M Urea, 20% glycerol, 0.2M NaCl
Molecular Mass: 23.5 kDa (202aa)
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRREAE KQNYLAEHCP PLHIPGSMSE VQELCKQLHA KIDAAEEEKY DMEVRVQKTS KELEDMNQKL FDLRGKFKRP PLRRVRMSAD AMLKALLGSK HKVCMDLRAN LKQVKKEDTE KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES
Purity: >90% by SDS - PAGE
Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration: 0.25 mg/ml (determined by Bradford assay)
Gene Name: TNNI2 troponin I type 2 (skeletal, fast) [ Homo sapiens ]
Official Symbol: TNNI2
Synonyms: TNNI2; troponin I type 2 (skeletal, fast); troponin I, skeletal, fast; troponin I, fast skeletal muscle; AMCD2B; DA2B; FSSV; troponin I fast twitch 2; troponin I; fast twitch skeletal muscle isoform; troponin I, fast-twitch isoform; fast-twitch skeletal muscle troponin I; troponin I, fast-twitch skeletal muscle isoform; fsTnI;
Gene ID: 7136
mRNA Refseq: NM_001145829
Protein Refseq: NP_001139301
MIM: 191043
UniProt ID: P48788
Chromosome Location: 11p15.5
Pathway: Muscle contraction, organism-specific biosystem; Striated Muscle Contraction, organism-specific biosystem; Striated Muscle Contraction, organism-specific biosystem;
Function: contributes_to actin binding; protein binding; troponin T binding;

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