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Recombinant Human RCAN family member 3, His-tagged

Cat.No.: RCAN3-372H
Product Overview: RCAN3, 56-241aa, Human, His tag, E.coli
Description: Calcipressin-3, also known as RCAN3, is a 241 amino acid protein that potentially is involved in central nervous system development. RCAN3 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Overexpression of calcipressin-3 results in inhibition of calcineurin activity towards the nuclear factor of activated T-cells (NFAT) transcription factors and also downregulates NFAT-dependent cytokine gene expression in activated Jurkat T-cells. Highest expression occurs in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Recombinant human RCAN3 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Source: E.coli
Species: Human
Tag: His-tag
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2M Urea, 20% glycerol, 0.2M NaCl
Molecular Mass: 23.5 kDa (209aa)
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSEAVFEAR EQKERFEALF TIYDDQVTFQ LFKSFRRVRI NFSKPEAAAR ARIELHETDF NGQKLKLYFA QVQMSGEVRD KSYLLPPQPV KQFLISPPAS PPVGWKQSED AMPVINYDLL CAVSKLGPGE KYELHAGTES TPSVVVHVCE SETEEEEETK NPKQKIAQTR RPDPPTAALN EPQTFDCAL
Purity: >90% by SDS - PAGE
Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration: 0.5 mg/ml (determined by Bradford assay)
Gene Name: RCAN3 RCAN family member 3 [ Homo sapiens ]
Official Symbol: RCAN3
Synonyms: RCAN3; RCAN family member 3; Down syndrome critical region gene 1 like 2 , DSCR1L2; calcipressin-3; regulator of calcineurin 3; Down syndrome candidate region 1-like 2; Down syndrome critical region gene 1-like 2; down syndrome candidate region 1-like protein 2; myocyte-enriched calcineurin-interacting protein 3; RCN3; MCIP3; hRCN3; DSCR1L2;
Gene ID: 11123
mRNA Refseq: NM_001251977
Protein Refseq: NP_001238906
MIM: 605860
UniProt ID: Q9UKA8
Chromosome Location: 1p35.3-p33
Function: RNA binding; nucleotide binding; troponin I binding;

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