Recombinant Human RCAN family member 3, His-tagged

• Cat.No.: RCAN3-372H
• Product Overview: RCAN3, 56-241aa, Human, His tag, E.coli

Specification

• Description: Calcipressin-3, also known as RCAN3, is a 241 amino acid protein that potentially is involved in central nervous system development. RCAN3 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Overexpression of calcipressin-3 results in inhibition of calcineurin activity towards the nuclear factor of activated T-cells (NFAT) transcription factors and also downregulates NFAT-dependent cytokine gene expression in activated Jurkat T-cells. Highest expression occurs in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Recombinant human RCAN3 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2M Urea, 20% glycerol, 0.2M NaCl
• Molecular Mass: 23.5 kDa (209aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSEAVFEAR EQKERFEALF TIYDDQVTFQ LFKSFRRVRI NFSKPEAAAR ARIELHETDF NGQKLKLYFA QVQMSGEVRD KSYLLPPQPV KQFLISPPAS PPVGWKQSED AMPVINYDLL CAVSKLGPGE KYELHAGTES TPSVVVHVCE SETEEEEETK NPKQKIAQTR RPDPPTAALN EPQTFDCAL
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: RCAN3 RCAN family member 3 [ Homo sapiens ]
• Official Symbol: RCAN3
• Synonyms: RCAN3; RCAN family member 3; Down syndrome critical region gene 1 like 2 , DSCR1L2; calcipressin-3; regulator of calcineurin 3; Down syndrome candidate region 1-like 2; Down syndrome critical region gene 1-like 2; down syndrome candidate region 1-like protein 2; myocyte-enriched calcineurin-interacting protein 3; RCN3; MCIP3; hRCN3; DSCR1L2
• Gene ID: 11123
• mRNA Refseq: NM_001251977
• Protein Refseq: NP_001238906
• MIM: 605860
• UniProt ID: Q9UKA8
• Chromosome Location: 1p35.3-p33
• Function: RNA binding; nucleotide binding; troponin I binding