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Recombinant Human poly(A) binding protein, nuclear 1, His-tagged

Cat.No. : PABPN1-403H
Product Overview : PABPN1, 119-306aa, Human, His tag, E.coli
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Description : PABPN1 is an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3" ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5" end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. Recombinant human PABPN1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Molecular Mass : 23.8 kDa (211aa)
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSLEAIKAR VREMEEEAEK LKELQNEVEK QMNMSPPPGN AGPVIMSIEE KMEADARSIY VGNVDYGATA EELEAHFHGC GSVNRVTILC DKFSGHPKGF AYIEFSDKES VRTSLALDES LFRGRQIKVI PKRTNRPGIS TTDRGFPRAR YRARTTNYNS SRSRFYSGFN SRPRGRVYRG RARATSWYSP Y
Purity : >95% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : PABPN1?poly(A) binding protein, nuclear 1 [?Homo sapiens?(human) ]
Official Symbol : PABPN1
Synonyms : PABPN1; OPMD; PAB2; PABII; PABP2; PABP-2; poly(A) binding protein, nuclear 1; polyadenylate-binding protein 2; poly(A) binding protein 2; poly(A) binding protein II
Gene ID : 8106
mRNA Refseq : NM_004643
Protein Refseq : NP_004634
MIM : 602279
UniProt ID : Q86U42
Chromosome Location : 14q11.2
Pathway : Cleavage of Growing Transcript in the Termination Region; Host Interactions with Influenza Factors; Inhibition of Host mRNA Processing and RNA Silencing
Function : RNA binding; nucleotide binding; poly(A) RNA binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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09/13/2019

    Their team of experts is not only knowledgeable about the PABPN1 protein but is also dedicated to assisting researchers like myself in overcoming any challenges that may arise.

    01/27/2019

      This high-quality protein is crucial for the success of my experiments, ensuring that I obtain reliable and meaningful scientific findings.

      12/14/2016

        Whether it's modifying protocols, providing custom formulations, or offering personalized recommendations, their flexibility ensures that I have the necessary tools to carry out my experiments seamlessly.

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