Recombinant Human kallikrein-related peptidase 15, His-tagged

• Cat.No.: KLK15-461H
• Product Overview: KLK15, 22-256aa, Human, His tag, E.coli

Specification

• Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK15 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, it has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. KLK15 contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. Recombinant human KLK15 protein, fused to His-tag at N-terminus, was expressed in E.coli .
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
• Molecular Mass: 28.2 kDa (258aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSLLEGDEC APHSQPWQVA LYERGRFNCG ASLISPHWVL SAAHCQSRFM RVRLGEHNLR KRDGPEQLRT TSRVIPHPRY EARSHRNDIM LLRLVQPARL NPQVRPAVLP TRCPHPGEAC VVSGWGLVSH NEPGTAGSPR SQVSLPDTLH CANISIISDT SCDKSYPGRL TNTMVCAGAE GRGAESCEGD SGGPLVCGGI LQGIVSWGDV PCDNTTKPGV YTKVCHYLEW IRETMKRN
• Purity: >90 % by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1.0 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: KLK15 kallikrein-related peptidase 15 [ Homo sapiens ]
• Official Symbol: KLK15
• Synonyms: KLK15; kallikrein-related peptidase 15; kallikrein 15; kallikrein-15; ACO; HSRNASPH; prostinogen; ACO protease; kallikrein-like serine protease
• Gene ID: 55554
• mRNA Refseq: NM_017509
• Protein Refseq: NP_059979
• MIM: 610601
• UniProt ID: Q9H2R5
• Chromosome Location: 19q13.4
• Function: catalytic activity; peptidase activity; serine-type endopeptidase activity; serine-type endopeptidase activity; serine-type peptidase activity