Recombinant Human keratin 17, His-tagged
Cat.No. : | KRT17-483H |
Product Overview : | KRT17, 1-432aa Human, His tag, E.coli |
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Description : | KRT17, as known as keratin17, is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. Recombinant human KRT17 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
Source : | E.coli |
Species : | Human |
Tag : | His-tag |
Form : | Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea |
Molecular Mass : | 50.5 kDa(455aa) |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSMTTSIRQ FTSSSSIKGS SGLGGGSSRT SCRLSGGLGA GSCRLGSAGG LGSTLGGSSY SSCYSFGSGG GYGSSFGGVD GLLAGGEKAT MQNLNDRLAS YLDKVRALEE ANTELEVKIR DWYQRQAPGP ARDYSQYYRT IEELQNKILT ATVDNANILL QIDNARLAAD DFRTKFETEQ ALRLSVEADI NGLRRVLDEL TLARADLEMQ IENLKEELAY LKKNHEEEMN ALRGQVGGEI NVEMDAAPGV DLSRILNEMR DQYEKMAEKN RKDAEDWFFS KTEELNREVA TNSELVQSGK SEISELRRTM QALEIELQSQ LSMKASLEGN LAETENRYCV QLSQIQGLIG SVEEQLAQLR CEMEQQNQEY KILLDVKTRL EQEIATYRRL LEGEDAHLTQ YKKEPVTTRQ VRTIVEEVQD GKVISSREQV HQTTR |
Purity : | >90% by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5mg/ml (determined by Bradford assay) |
Gene Name : | KRT17 keratin 17 [ Homo sapiens ] |
Official Symbol : | KRT17 |
Synonyms : | KRT17; keratin 17; PCHC1; keratin, type I cytoskeletal 17; 39.1; CK-17; keratin-17; cytokeratin-17; keratin 17 epitope S1; keratin 17 epitope S2; keratin 17 epitope S4; PC; K17; PC2; |
Gene ID : | 3872 |
mRNA Refseq : | NM_000422 |
Protein Refseq : | NP_000413 |
MIM : | 148069 |
UniProt ID : | Q04695 |
Chromosome Location : | 17q21.2 |
Pathway : | EGFR1 Signaling Pathway, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; |
Function : | protein binding; structural constituent of cytoskeleton; |
Products Types
◆ Recombinant Protein | ||
KRT17-611B | Recombinant Bovine KRT17 Protein (1-441 aa), His-SUMO-tagged | +Inquiry |
KRT17-4913M | Recombinant Mouse KRT17 Protein, His (Fc)-Avi-tagged | +Inquiry |
KRT17-2970R | Recombinant Rat KRT17 Protein, His (Fc)-Avi-tagged | +Inquiry |
KRT17-2826H | Recombinant Human KRT17 protein(71-400 aa), C-His-tagged | +Inquiry |
Krt17-12R | Recombinant Rat Krt17 protein, His-tagged | +Inquiry |
◆ Lysates | ||
KRT17-953HCL | Recombinant Human KRT17 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, elevated levels of KRT17 protein have been associated with poorer prognosis and higher risk of disease recurrence in cancer patients.
Yes, changes in KRT17 protein levels during treatment can serve as a potential biomarker for assessing treatment response and guiding personalized cancer therapy.
Studies have suggested that higher KRT17 protein levels may be associated with increased metastatic potential in certain types of cancer.
KRT17 protein is typically expressed at low levels in normal tissue, but its expression is significantly upregulated in cancerous tissue.
Yes, immunohistochemistry and immunofluorescence assays are commonly used to measure KRT17 protein expression in cancer tissue samples.
Customer Reviews (3)
Write a reviewWith its purity and reliability, this protein is poised to contribute significantly to the success of my research objectives by providing accurate and reproducible results.
The KRT17 Protein demonstrates remarkable stability and functional efficiency, making it an indispensable tool for diverse scientific applications.
Its versatility allows for exploration of its extensive involvement in various biochemical and biological processes, providing valuable insights into its role and implications.
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