"LOX" Related Products

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Recombinant Human lysyl oxidase, His-tagged

Cat.No.: LOX-608H
Product Overview: LOX, 169-417aa, Human, His tag, E.coli
Description: LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. Recombinant human LOX protein, fused to His-tag at N-terminus, was expressed in E.coli.
Source: E.coli
Species: Human
Tag: His-tag
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Molecular Mass: 31.4 kDa (272aa)
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSDDPYNPY KYSDDNPYYN YYDTYERPRP GGRYRPGYGT GYFQYGLPDL VADPYYIQAS TYVQKMSMYN LRCAAEENCL ASTAYRADVR DYDHRVLLRF PQRVKNQGTS DFLPSRPRYS WEWHSCHQHY HSMDEFSHYD LLDANTQRRV AEGHKASFCL EDTSCDYGYH RRFACTAHTQ GLSPGCYDTY GADIDCQWID ITDVKPGNYI LKVSVNPSYL VPESDYTNNV VRCDIRYTGH HAYASGCTIS PY
Purity: >85% by SDS - PAGE
Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml (determined by Bradford assay)
Gene Name: LOX lysyl oxidase [ Homo sapiens ]
Official Symbol: LOX
Synonyms: LOX; lysyl oxidase; protein-lysine 6-oxidase; MGC105112;
Gene ID: 4015
mRNA Refseq: NM_001178102
Protein Refseq: NP_001171573
MIM: 153455
UniProt ID: P28300
Chromosome Location: 5q23.3-q31.2
Function: copper ion binding; metal ion binding; oxidoreductase activity; protein-lysine 6-oxidase activity;

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