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Recombinant Rat Anks1b, His-tagged

Cat.No. : Anks1b-3474R
Product Overview : Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Anks1b), partial
  • Specification
  • Gene Information
  • Related Products
Source : E. Coli or Yeast
Species : Rat
Tag : His
Form : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Protein length : 1260
Purity : >90%
Notes : Small volumes of Anks1b recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Storage Buffer : PBS pH 7.4, 50% glycerol
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : Anks1b ankyrin repeat and sterile alpha motif domain containing 1B [ Rattus norvegicus ]
Official Symbol : Anks1b
Synonyms : ANKS1B; ankyrin repeat and sterile alpha motif domain containing 1B; RGD1565556;
Gene ID : 314721
Function : ephrin receptor binding; ephrin receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (15)

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Can Anks1B be targeted for therapeutic interventions? 06/28/2021

The potential therapeutic targeting of Anks1B has not been extensively explored. However, given its involvement in cancer progression and metastasis, it may represent a potential therapeutic target for cancer therapies aimed at inhibiting cell migration and invasion. Further research is needed to evaluate its clinical relevance and potential as a therapeutic target.

What are the known interacting partners of Anks1B? 03/08/2021

Anks1B has been shown to interact with various proteins, including β-catenin, Rho GTPases (such as RhoA and Rac1), and the actin cytoskeleton regulator ERM (Ezrin, Radixin, Moesin) proteins. These interactions suggest that Anks1B may participate in multiple signaling pathways involved in cell adhesion, migration, and cytoskeletal dynamics.

Are there any animal models or knockout studies related to Anks1B? 02/22/2021

Yes, animal models and knockout studies have been conducted to investigate the role of Anks1B in development and disease. Mice with Anks1B gene knockout display defects in tissue morphogenesis and cell migration, leading to abnormalities in organ development. These studies provide valuable insights into the physiological functions of Anks1B.

Are there any known interactors of Anks1B protein? 01/31/2021

Yes, Anks1B interacts with several proteins. One of its known interactors is Anks1A, forming a complex together. Anks1B also interacts with proteins such as β-catenin and LIMK1, which are involved in actin cytoskeleton regulation, and may modulate their activities.

Are there any known disease associations or mutations in the Anks1B gene? 01/04/2021

Mutations in the Anks1B gene have been linked to certain genetic disorders, including KBG syndrome. KBG syndrome is characterized by intellectual disability, short stature, skeletal abnormalities, and distinctive craniofacial features. These mutations may lead to alterations in Anks1B protein function and disrupt its normal cellular processes, contributing to the development of these disorders.

Can Anks1B be used as a biomarker for any diseases? 10/27/2020

Currently, there is no evidence to suggest that Anks1B can be used as a biomarker for specific diseases. However, its association with cancer progression and metastasis suggests that further research may explore its potential as a diagnostic or prognostic marker in certain cancer types.

Is there any tissue-specific expression pattern for Anks1B? 10/10/2019

Yes, Anks1B exhibits a tissue-specific expression pattern. It is found to be highly expressed in tissues that undergo active morphogenetic movements, such as developing embryos, neural tissues, and certain adult tissues including the brain, heart, and testis.

Does Anks1B have any known roles in cancer? 08/22/2018

Yes, Anks1B has been implicated in cancer progression and metastasis. Studies have shown that Anks1B expression is elevated in various cancer types, including breast, colorectal, and ovarian cancers. It has been suggested that Anks1B promotes tumor cell migration and invasion through its involvement in cytoskeletal organization and cell adhesion.

Is Anks1B expressed in specific tissues or cell types? 07/18/2018

Anks1B is expressed in a wide range of tissues and cell types. It is detected in various organs, including the brain, heart, liver, and skeletal muscle. Within these tissues, Anks1B expression can be localized to specific cell types, such as neurons in the brain or cardiomyocytes in the heart. The specific expression pattern of Anks1B may reflect its diverse functions in different cellular contexts.

Is there any evidence for Anks1B protein involvement in cell signaling pathways? 04/24/2018

Yes, there is evidence suggesting that Anks1B is involved in different cell signaling pathways. Anks1B has been shown to interact with β-catenin, a key component of the Wnt signaling pathway, and modulate its activity. Additionally, Anks1B has been implicated in the regulation of RhoA and Rac1 signaling, both of which play important roles in cytoskeletal dynamics and cell migration.

What are the molecular mechanisms underlying the functions of Anks1B? 04/19/2018

he molecular mechanisms underlying the functions of Anks1B are still being elucidated. However, some studies have provided insights into its roles. Anks1B has been shown to interact with β-catenin, a key component of the Wnt signaling pathway, and regulate the transcriptional activity of β-catenin in a context-dependent manner. This suggests that Anks1B may influence cell fate determination and tissue development through its involvement in Wnt signaling.

What functional roles does Anks1B play in cellular processes? 03/11/2018

Anks1B is involved in various cellular processes, including cell adhesion, migration, and cytoskeletal organization. It interacts with proteins that regulate the actin cytoskeleton, which is essential for cell shape, movement, and intracellular transport. Anks1B also participates in signaling pathways, such as the Wnt signaling pathway, that control cell fate determination and tissue development.

What are the consequences of Anks1B dysfunction or depletion? 10/26/2017

Dysfunction or depletion of Anks1B can lead to various cellular defects and physiological consequences. In animal models, Anks1B knockout has been associated with abnormalities in tissue morphogenesis, skeletal development, and cell migration. These defects can have severe consequences on organ development and may contribute to the pathogenesis of certain diseases or genetic disorders.

Are there any disease associations with Anks1B mutations? 08/10/2017

Mutations in the ANKS1B gene have been associated with neurodevelopmental disorders, similar to the related ANKS1A gene. Variants in ANKS1B have been reported in individuals with autism spectrum disorders and intellectual disabilities, suggesting a potential role in the pathogenesis of these conditions. However, more research is needed to fully understand the impact of ANKS1B mutations on disease development.

Are there any therapeutic implications of targeting Anks1B? 04/06/2016

Targeting Anks1B could have therapeutic implications, particularly in conditions or diseases where its dysregulation or dysfunction is implicated. For example, in diseases such as KBG syndrome associated with Anks1B mutations, therapeutic strategies aimed at correcting or compensating for the mutant Anks1B protein could potentially ameliorate the disease phenotype.

Customer Reviews (4)

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Reviews
09/05/2022

    the ease of use and compatibility of the Anks1b protein with various techniques further enhances its appeal.

    12/15/2021

      One of the standout features of the Anks1b protein is the excellent technical support provided by the manufacturer.

      09/06/2021

        The Anks1b protein is a top-quality product that is sure to fulfill my experimental requirements.

        12/02/2020

          Whether I need to study protein-protein interactions, protein localization, or protein folding, the Anks1b protein consistently delivers precise and meaningful data.

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