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Recombinant Human ApoE4

Cat.No. : ApoE4-3563H
Product Overview : ApoE4
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  • Gene Information
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Description : Purified recombinant Human ApoE4 proteinApoE4 is the high risk variant of the APOE gene, the gene most associated with increased risk for late-onset Alzheimer"s disease. Wikipedia shows that it is not a direct determinant of the disease - at least a third of patients with Alzheimer"s disease are ApoE4 negative and some ApoE4 homozygotes never develop the disease. Yet those with ApoE4/ApoE4 have ~20x risk of developing Alzheimer"s.
Source : E.coli
Species : Human
Form : Sterile filtered through a 0.2 micron filter. Lyophilized from 20mM Sodium Phosphate, pH 7.8. Centrifuge prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do NOT vortex.
Molecular Mass : 34.4 kDa
AA Sequence : Region of ApoE4 protein corresponding to amino acids MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVRGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE
Endotoxin : Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Purity : >90% pure by SDS PAGE analysis.
Notes : Small volumes of ApoE4 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Upon receipt, product is stable while lyophilized at room temperature for 1 month, 4 degree C for 6 months and -20 degree for 2 years. Once reconstituted, can be stored at 4 degree C for 1 week. Stable for 3 months when further diluted in a buffer with a carrier protein and stored in aliquots at -20 degree C.
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : ApoE4
Official Symbol : ApoE4
Gene Name : ApoE4
Official Symbol : ApoE4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (16)

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Does everyone who carries ApoE4 develop Alzheimer's disease? 04/27/2023

No, not everyone who carries ApoE4 develops Alzheimer's disease. While ApoE4 is a risk factor, it is not a guaranteed predictor. Many other genetic, environmental, and lifestyle factors can influence an individual's susceptibility to AD, and individuals without ApoE4 can also develop the disease.

Are there any ongoing research efforts targeting the ApoE4 protein? 04/16/2023

Yes, there are ongoing research efforts focused on targeting the ApoE4 protein to develop potential therapies for Alzheimer's disease. This includes investigating strategies to modulate its expression, enhance its clearance, or neutralize its pathological effects. Additionally, studies are being conducted to better understand the underlying mechanisms of ApoE4-associated neurodegeneration and to identify other molecular targets that may be involved in the disease process. Such research aims to develop novel interventions to prevent or treat Alzheimer's disease in individuals with ApoE4.

How does the ApoE4 protein affect amyloid-beta aggregation in Alzheimer's disease? 11/09/2022

ApoE4 has been shown to modulate the aggregation and clearance of amyloid-beta plaques in the brain, which are a hallmark of Alzheimer's disease. Compared to other ApoE variants, ApoE4 is less efficient in facilitating the clearance of amyloid-beta, leading to its accumulation and formation of toxic plaques.

Is there ongoing research focused on targeting ApoE4 for Alzheimer's disease treatment? 04/19/2022

Yes, there is significant ongoing research focused on targeting ApoE4 for potential Alzheimer's disease treatments. Scientists are exploring various approaches, such as developing drugs to modulate ApoE4's pathological effects, enhancing ApoE2's protective effects, and using gene-editing techniques to modify ApoE4 in the brain cells. These efforts aim to prevent or slow down the progression of AD in individuals with ApoE4.

Is there a way to reduce the expression or impact of ApoE4 in the brain? 04/23/2021

Researchers are exploring various approaches to reduce the expression or impact of ApoE4 in the brain. This includes gene silencing techniques, such as using antisense oligonucleotides, to manipulate the expression of ApoE4. Additionally, strategies like promoting ApoE2 expression or enhancing protein degradation pathways are being investigated to mitigate the detrimental effects of ApoE4.

Can lifestyle modifications reduce the risk of Alzheimer's disease for individuals with ApoE4? 12/27/2020

Yes, adopting a healthy lifestyle can potentially reduce the risk of Alzheimer's disease even for individuals with ApoE4. Regular exercise, a balanced diet, maintaining mental and social stimulation, managing cardiovascular risk factors, and getting sufficient sleep are all considered beneficial in reducing the risk or delaying the onset of AD.

Can ApoE4 be used as a diagnostic marker for Alzheimer's disease? 04/15/2020

While ApoE4 is a genetic risk factor for Alzheimer's disease, it is not used as a definitive diagnostic marker. The presence of ApoE4 can be determined through a genetic test, but clinical diagnosis of AD usually involves assessing a combination of medical history, cognitive tests, brain imaging, and other biomarkers.

Are there any lifestyle factors or interventions that can mitigate the risk associated with ApoE4? 12/01/2019

Yes, certain lifestyle factors and interventions have been shown to potentially mitigate the risk associated with ApoE4. Regular physical exercise, a heart-healthy diet (such as the Mediterranean diet), maintaining a healthy weight, managing blood pressure and cholesterol levels, and avoiding smoking are all beneficial for overall brain health and may help reduce the risk of developing Alzheimer's disease, even in individuals with ApoE4. Additionally, engaging in mentally stimulating activities, staying socially active, getting adequate sleep, and managing stress effectively may also contribute to minimizing the impact of ApoE4.

Can the expression of ApoE4 be modified through lifestyle changes or interventions? 10/15/2019

While lifestyle changes and interventions cannot modify an individual's genetic makeup or change the presence of the ApoE4 allele, they can potentially influence the impact of ApoE4 on disease risk and progression. Certain lifestyle factors, such as those mentioned earlier (regular exercise, healthy diet, mental stimulation, etc.), have been associated with a lower risk of Alzheimer's disease, regardless of ApoE genotype. Managing modifiable risk factors can potentially improve overall brain health and reduce the risk of developing Alzheimer's disease, even in individuals with ApoE4.

Can the presence of ApoE4 affect the response to certain medications or therapies? 03/20/2019

Yes, the presence of ApoE4 can potentially influence an individual's response to certain medications or therapies. It has been suggested that ApoE4 carriers may have different responses to drugs targeting amyloid-beta or other pathways involved in Alzheimer's disease treatment. Understanding an individual's ApoE genotype may help personalize treatment strategies.

Are there any other diseases or conditions associated with the ApoE4 protein? 06/30/2017

Besides its association with Alzheimer's disease, ApoE4 has also been linked to an increased risk of other neurological disorders, including cognitive decline, dementia with Lewy bodies, and cerebral amyloid angiopathy. Additionally, ApoE4 may play a role in cardiovascular diseases, such as heart disease and stroke.

Are there other variants of the ApoE protein besides ApoE4? 05/27/2017

Yes, besides ApoE4, there are also two other common variants of the ApoE protein: ApoE2 and ApoE3. ApoE2 is considered to have a protective effect against Alzheimer's disease, while ApoE3 is the most common variant and does not significantly increase or decrease the risk of developing the disease.

How is the ApoE4 protein involved in lipid metabolism? 05/23/2017

The ApoE4 protein plays a crucial role in lipid metabolism by serving as a carrier protein for lipids, particularly cholesterol, throughout the body. It interacts with specific receptors on cell surfaces, facilitating the uptake and metabolism of lipoproteins, which are responsible for transporting lipids in the bloodstream.

Is it possible to test for the presence of ApoE4? 11/03/2016

Yes, it is possible to test for the presence of the ApoE4 allele through genetic testing. This can be done using a simple DNA sample, usually obtained through a saliva or blood sample. However, it is important to consider the implications and limitations of genetic testing, as the presence of ApoE4 does not definitively predict the development or severity of Alzheimer's disease. Genetic testing results should be interpreted in the context of an individual's overall health and risk factors.

How is the ApoE4 protein related to Alzheimer's disease? 08/21/2016

ApoE4 is a major genetic risk factor for late-onset Alzheimer's disease (AD). Individuals carrying one copy of the ApoE4 allele have an increased risk, while those with two copies have an even higher risk. It is thought that ApoE4 contributes to AD pathogenesis through its effects on amyloid-beta aggregation, tau pathology, and neuroinflammation.

Does the ApoE4 protein have any known normal physiological functions? 01/29/2016

Yes, the ApoE4 protein has several normal physiological functions. It plays a key role in the transport of lipids, particularly cholesterol, in the body. ApoE4 is important for liver function, including the clearance of lipoproteins and the regulation of lipid levels in the blood. It also has functions in the brain, such as neuronal growth and repair processes. However, its role in Alzheimer's disease pathogenesis pertains to its specific pathological effects.

Customer Reviews (3)

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Reviews
06/17/2022

    This guidance allows me to design and implement experiments effectively while adhering to best practices, enhancing the reliability and reproducibility of my results.

    08/29/2019

      One major advantage of ApoE4 protein is its ability to contribute to the understanding of diseases related to aberrant cell cycle regulation, including cancer.

      04/30/2018

        The manufacturer of ApoE4 protein plays a crucial role in supporting my research efforts.

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