Recombinant Mouse Abca1, His-tagged

• Cat.No.: Abca1-3728M
• Product Overview: ATP-binding cassette sub-family A member 1 (Abca1), partial

Specification

• Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier"s disease and familial high-density lipoprotein deficiency.
• Source: E. Coli or Yeast
• Species: Mouse
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 2261
• Purity: >90%
• Notes: Small volumes of Abca1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 [ Mus musculus ]
• Official Symbol: Abca1
• Synonyms: ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette 1; ATP-binding cassette transporter 1; Abc1; ABC-1
• Gene ID: 11303
• mRNA Refseq: NM_013454
• Protein Refseq: NP_038482
• Chromosome Location: Chromosome: 4; NC_000070.6 (53030789..53159988, complement)
• Pathway: ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; Fat digestion and absorption, organism-specific biosystem; Fat digestion and absorption, conserved biosystem; HDL-mediated lipid transport, organism-specific biosystem
• Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; anion transmembrane transporter activity; apolipoprotein A-I binding; apolipoprotein A-I receptor activity; apolipoprotein binding; cholesterol transporter activity; cholesterol transporter activity; cholesterol transporter activity; nucleoside-triphosphatase activity; nucleotide binding; phospholipid transporter activity; phospholipid transporter activity; phospholipid transporter activity; protein binding; small GTPase binding; syntaxin binding