Recombinant Rat Abcg8, His-tagged
Cat.No. : | Abcg8-3742R |
Product Overview : | ATP-binding cassette sub-family G member 8 (Abcg8) |
- Specification
- Gene Information
- Related Products
Description : | ATP-binding cassette (ABC) transporter that regulates sterol absorption and excretion; mutation causes sitosterolemia . |
Source : | E. Coli or Yeast |
Species : | Rat |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 672 |
Purity : | >90% |
Notes : | Small volumes of Abcg8 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | Abcg8 ATP-binding cassette, subfamily G (WHITE), member 8 [ Rattus norvegicus ] |
Official Symbol : | Abcg8 |
Synonyms : | ABCG8; ATP-binding cassette, subfamily G (WHITE), member 8; ATP-binding cassette sub-family G member 8; sterolin 2; sterolin-2; ATP-binding cassette, sub-family G (WHITE), member 8; |
Gene ID : | 155192 |
mRNA Refseq : | NM_130414 |
Protein Refseq : | NP_569098 |
Chromosome Location : | 6q12 |
Pathway : | ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Fat digestion and absorption, organism-specific biosystem; Fat digestion and absorption |
Function : | ATP binding; contributes_to ATP binding; ATPase activity; contributes_to ATPase activity; contributes_to cholesterol transporter activity; cholesterol transporter activity; nucleotide binding; protein heterodimerization activity; sterol transporter activity; |
Products Types
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Abcg8-8152R | Recombinant Rat Abcg8 protein, His & T7-tagged | +Inquiry |
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ABCG8-416R | Recombinant Rat ABCG8 Protein | +Inquiry |
◆ Lysates | ||
ABCG8-9141HCL | Recombinant Human ABCG8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionTo a lesser extent, NPC1L1 rs217434 variants increase the risk of early-onset gallstone formation.
Single nucleotide polymorphisms (SNPs) in ABCG8 transporter have been associated with hypercholesterolemia.
lt will cause extremely low biliary cholesterol concentrations while biliary phospholipids and bile acid concentrations are not altered.
Mice lacking leptin, exhibit decreased abundance of ABCG8 proteins in the liver.
It will potentially induce atherosclerosis because of reduced circulating and hepatic cholesterol.
both anti-ABCG5 and anti-ABCG8 antibodies bound to ~75 kDa proteins in human liver crude membranes.
One study constructed mouse models deficient in either Abcg5 or Abcg8 that show different biliary physiology than that of the Abcg5/Abcg8 double knockout mice. This suggests these proteins may have independent function(s) in addition to their function as heterodimers.
ABCG8 appear to line the brush border.
Disruptions of bile acid metabolism alter hepatic ABCG5/G8 expression.
ABCG5 and ABCG8 are co-regulated at the transcriptional level, sharing a common bidirectional promoter of 374 base pairs that separates their initiation codons, cause sitosterolemia as well.
Customer Reviews (2)
Write a reviewGood work in immunohistochemistry
The purification rsults demonstrtaed clearly! Great.
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