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Recombinant Rat Abcg8, His-tagged

Cat.No. : Abcg8-3742R
Product Overview : ATP-binding cassette sub-family G member 8 (Abcg8)
  • Specification
  • Gene Information
  • Related Products
Description : ATP-binding cassette (ABC) transporter that regulates sterol absorption and excretion; mutation causes sitosterolemia .
Source : E. Coli or Yeast
Species : Rat
Tag : His
Form : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Protein length : 672
Purity : >90%
Notes : Small volumes of Abcg8 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Storage Buffer : PBS pH 7.4, 50% glycerol
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : Abcg8 ATP-binding cassette, subfamily G (WHITE), member 8 [ Rattus norvegicus ]
Official Symbol : Abcg8
Synonyms : ABCG8; ATP-binding cassette, subfamily G (WHITE), member 8; ATP-binding cassette sub-family G member 8; sterolin 2; sterolin-2; ATP-binding cassette, sub-family G (WHITE), member 8;
Gene ID : 155192
mRNA Refseq : NM_130414
Protein Refseq : NP_569098
Chromosome Location : 6q12
Pathway : ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Fat digestion and absorption, organism-specific biosystem; Fat digestion and absorption
Function : ATP binding; contributes_to ATP binding; ATPase activity; contributes_to ATPase activity; contributes_to cholesterol transporter activity; cholesterol transporter activity; nucleotide binding; protein heterodimerization activity; sterol transporter activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What may happen if the allele in ABCG8, NPC1L1 rs217434 mutated? 04/14/2023

To a lesser extent, NPC1L1 rs217434 variants increase the risk of early-onset gallstone formation.

what biological variation may influence the association between ABCG8 transporters and hypercholesterolemia? 04/14/2023

Single nucleotide polymorphisms (SNPs) in ABCG8 transporter have been associated with hypercholesterolemia.

What will happen if disrupt both ABCG5 and ABCG8 in mice? 04/14/2023

lt will cause extremely low biliary cholesterol concentrations while biliary phospholipids and bile acid concentrations are not altered.

What is the relationship between ABCG8 and leptin in mice? 04/14/2023

Mice lacking leptin, exhibit decreased abundance of ABCG8 proteins in the liver.

What will the overexpression of ABCG8 genes cause? 04/14/2023

It will potentially induce atherosclerosis because of reduced circulating and hepatic cholesterol.

What results can you found through western blot experiment results? 04/14/2023

both anti-ABCG5 and anti-ABCG8 antibodies bound to ~75 kDa proteins in human liver crude membranes.

What is the difference between deficient in either Abcg5 or Abcg8 and double missing? 04/14/2023

One study constructed mouse models deficient in either Abcg5 or Abcg8 that show different biliary physiology than that of the Abcg5/Abcg8 double knockout mice. This suggests these proteins may have independent function(s) in addition to their function as heterodimers.

What is the distribution pattern of ABCG8 in small intestine ? 04/14/2023

 ABCG8 appear to line the brush border.

What changes can affect the expression of ABCG8? 04/14/2023

Disruptions of bile acid metabolism alter hepatic ABCG5/G8 expression.

What is the relationship between ABCG5 and ABCG8? 04/14/2023

ABCG5 and ABCG8 are co-regulated at the transcriptional level, sharing a common bidirectional promoter of 374 base pairs that separates their initiation codons, cause sitosterolemia as well.

Customer Reviews (2)

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Reviews
08/01/2019

    Good work in immunohistochemistry

    04/21/2018

      The purification rsults demonstrtaed clearly! Great.

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