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Recombinant Human HUWE1, GST-tagged

Cat.No. : HUWE1-14015H
Product Overview : Recombinant Human HUWE1(4281 a.a. - 4374 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.
  • Specification
  • Gene Information
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Description : This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation.
Source : Wheat germ
Species : Human
Tag : GST
Molecular Mass : 36.08 kDa
AA Sequence : FWRALRSFDQADRAKFLQFVTGTSK VPLQGFAALEGMNGIQKFQIHRDDR STDRLPSAHTCFNQLDLPAYESFEK LRHMLLLAIQECSEGFGLA
Applications : ELISA; WB-Re; AP; Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase [ Homo sapiens ]
Official Symbol : HUWE1
Synonyms : HUWE1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; HECT, UBA and WWE domain containing 1; E3 ubiquitin-protein ligase HUWE1; Ib772; KIAA0312; UREB1; ARF-binding protein 1; URE-binding protein 1; BJ-HCC-24 tumor antigen; large structure of UREB1; HECT domain protein LASU1; Mcl-1 ubiquitin ligase E3; upstream regulatory element-binding protein 1; homologous to E6AP carboxyl terminus homologous protein 9; MULE; LASU1; HECTH9; URE-B1; ARF-BP1; HSPC272
Gene ID : 10075
mRNA Refseq : NM_031407
Protein Refseq : NP_113584
MIM : 300697
UniProt ID : Q7Z6Z7
Chromosome Location : Xp11.22
Pathway : Adaptive Immune System; Antigen processing: Ubiquitination & Proteasome degradation; Class I MHC mediated antigen processing & presentation
Function : DNA binding; poly(A) RNA binding; protein binding; ubiquitin-protein ligase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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