Recombinant Human MSH6, GST-tagged
Cat.No. : | MSH6-2414H |
Product Overview : | Recombinant Human MSH6(931 a.a. - 1030 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 36.74 kDa |
AA Sequence : | AGFDSDYDQALADIRENEQSLLEYL EKQRNRIGCRTIVYWGIGRNRYQLE IPENFTTRNLPEEYELKSTKKGCKR YWTKTIEKKLANLINAEERRDVSLK |
Applications : | ELISA; WB-Re; AP; Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | MSH6 mutS homolog 6 [ Homo sapiens (human) ] |
Official Symbol : | MSH6 |
Synonyms : | MSH6; GTBP; HSAP; p160; GTMBP; HNPCC5; mutS homolog 6; DNA mismatch repair protein Msh6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein |
Gene ID : | 2956 |
mRNA Refseq : | NM_000179 |
Protein Refseq : | NP_000170 |
MIM : | 600678 |
UniProt ID : | P52701 |
Chromosome Location : | 2p16 |
Pathway : | BRCA1-associated genome surveillance complex (BASC); Colorectal cancer; Mismatch repair |
Function : | contributes_to ADP binding; contributes_to ATPase activity; contributes_to MutLalpha complex binding |
Products Types
◆ Recombinant Protein | ||
MSH6-5740M | Recombinant Mouse MSH6 Protein, His (Fc)-Avi-tagged | +Inquiry |
MSH6-2693R | Recombinant Rhesus Macaque MSH6 Protein, His (Fc)-Avi-tagged | +Inquiry |
MSH6-03H | Recombinant Human MSH6 Protein, N-His tagged | +Inquiry |
MSH6-3246H | Recombinant Human MSH6 protein, His-SUMO-tagged | +Inquiry |
MSH6-2412H | Recombinant Human MSH6, GST-tagged | +Inquiry |
◆ Lysates | ||
MSH6-4117HCL | Recombinant Human MSH6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket