Active Recombinant Human TIMP1, HIgG1 Fc-tagged

• Cat.No.: TIMP1-002H
• Product Overview: The extracellular domain of human TIMP1(AAH00866.1)(Cys24-Ala207) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell .

Specification

• Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of thematrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. Inaddition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cellproliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of thisgene is highly inducible in response to many cytokines and hormones. In addition, the expression from some butnot all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene islocated within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
• Source: CHO cell
• Species: Human
• Tag: HIgG1 Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to induce alkaline phosphatase production .
• Molecular Mass: 47KDa (monomer)
• AA Sequence: Cys24-Ala207
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: TIMP1 TIMP metallopeptidase inhibitor 1 [ Homo sapiens ]
• Official Symbol: TIMP1
• Synonyms: TIMP1; TIMP metallopeptidase inhibitor 1; CLGI, TIMP, tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); metalloproteinase inhibitor 1; EPO; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1; EPA; HCI; CLGI; TIMP; FLJ90373
• Gene ID: 7076
• mRNA Refseq: NM_003254
• Protein Refseq: NP_003245
• MIM: 305370
• UniProt ID: P01033
• Chromosome Location: Xp11.3-p11.23
• Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Hemostasis, organism-specific biosystem; IL6-mediated signaling events, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem
• Function: enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; protein binding