"IL1A" Related Products

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Recombinant Human Il1A, HIgG1 Fc-tagged

Cat.No.: Il1A-26682H
Product Overview: The extracellular domain of human IL-1a (NP_000566.3)(Ser113-Ala271) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropiccytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine isproduced by monocytes and macrophages as a proprotein, which is proteolytically processed and released inresponse to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form acytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associatedwith rheumatoid arthritis and Alzheimer"s disease.
Source: CHO cell
Species: Human
Tag: HIgG1 Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: cytokine activity; interleukin-1 receptor binding; protein binding
Molecular Mass: 44KDa (monomer)
AA Sequence: Ser113-Ala271
Endotoxin: <0.06 eu/μg as determined by lal>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: IL1A interleukin 1, alpha [ Homo sapiens ]
Official Symbol: IL1A
Synonyms: IL1A; interleukin 1, alpha; IL1; interleukin-1 alpha; hematopoietin 1; IL 1A; IL1 ALPHA; IL1F1; preinterleukin 1 alpha; pro interleukin 1 alpha; IL-1 alpha; hematopoietin-1; pro-interleukin-1-alpha; IL-1A; IL1-ALPHA;
Gene ID: 3552
mRNA Refseq: NM_000575
Protein Refseq: NP_000566
MIM: 147760
UniProt ID: P01583
Chromosome Location: 2q14
Pathway: Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem;
Function: copper ion binding; cytokine activity; interleukin-1 receptor binding; protein binding;

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