Active Recombinant Human NGF, MIgG2a Fc-tagged
Cat.No. : | NGF-002H |
Product Overview : | The extracellular domain of human NGF(AAI26149.1)(Met1-Ala241) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell. |
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Description : | This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and isincorporated into a larger complex. This protein has nerve growth stimulating activity and the complex isinvolved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons.Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), anddysregulation of this gene"s expression is associated with allergic rhinitis. |
Source : | CHO cell |
Species : | Human |
Tag : | MIgG2a Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. |
Molecular Mass : | 40KDa (monomer) |
AA Sequence : | Met1-Ala241 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | NGF nerve growth factor (beta polypeptide) [ Homo sapiens ] |
Official Symbol : | NGF |
Synonyms : | NGF; nerve growth factor (beta polypeptide); NGFB; beta-nerve growth factor; nerve growth factor, beta subunit; HSAN5; Beta-NGF; MGC161426; MGC161428; |
Gene ID : | 4803 |
mRNA Refseq : | NM_002506 |
Protein Refseq : | NP_002497 |
MIM : | 162030 |
UniProt ID : | P01138 |
Chromosome Location : | 1p13.1 |
Pathway : | ARMS-mediated activation, organism-specific biosystem; Activation of TRKA receptors, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Axonal growth stimulation, organism-specific biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Ceramide signalling, organism-specific biosystem; |
Function : | growth factor activity; nerve growth factor receptor binding; receptor signaling protein activity; |
Products Types
◆ Recombinant Protein | ||
Ngf-1152R | Recombinant Rat Ngf Protein, His-tagged | +Inquiry |
NGF-091H | Active Recombinant Human NGF Protein | +Inquiry |
Ngf-489R | Recombinant Rat Ngf Protein(124-241aa), His-tagged | +Inquiry |
Ngf-4407M | Recombinant Mouse Ngf Protein, Myc/DDK-tagged | +Inquiry |
Ngf-1826R | Recombinant Rat Ngf Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
Ngf-182M | Active Native Mouse Ngf Protein | +Inquiry |
Ngf-51M | Native Mouse Nerve Growth Factor 2.5S | +Inquiry |
Ngf-298M | Active Native Mouse Nerve Growth Factor | +Inquiry |
◆ Lysates | ||
NGF-001HCL | Recombinant Human NGF cell lysate | +Inquiry |
NGF-001MCL | Recombinant Mouse NGF cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionStudies have shown that NGF protein plays a role in the occurrence and development of pain. It stimulates the growth and survival of sensory neurons and enhances their ability to transmit signals, thereby increasing pain sensation. In addition, NGF can interact with other pain-related molecules to modulate pain perception and tolerance.
There are a variety of drug development treatments that target NGF proteins and their related signaling pathways, including direct administration of NGF proteins, use of their analogues, or drugs that inhibit its degradation. These treatments are in clinical trials and are expected to provide new options for the treatment of neurological disorders.
NGF proteins interact with target cells by binding to their receptors. It binds to TrkA receptors on the surface of target cells, triggering a series of signal transduction mechanisms that ultimately influence the biological behavior of target cells.
In addition to its important role in the nervous system, NGF proteins can also affect the function of other systems. For example, NGF proteins can affect the function of the immune system, involved in inflammatory responses and the development of autoimmune diseases.
The function of NGF protein in glial cells is mainly to regulate its proliferation, differentiation and apoptosis. In addition, NGF promotes the repair and regeneration of damaged neurons by glial cells.
NGF proteins have a variety of biological activities, including promoting neuronal growth, differentiation, survival, and repair of damage, regulating connections and signaling between neurons, and influencing the function of other systems.
Customer Reviews (3)
Write a reviewHigh catalytic efficiency, high safety and high expression level of the protein make it perform well in many experiments.
The short half-life and high clearance of NGF make it possible to better control the concentration and action time of drugs in the body, so as to better control the therapeutic effect.
This production process of NGF pays attention to the recycling of resources and minimizes waste, which is very consistent with the principle of green production.
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