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Active Recombinant Human NGF, MIgG2a Fc-tagged

Cat.No. : NGF-002H
Product Overview : The extracellular domain of human NGF(AAI26149.1)(Met1-Ala241) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.
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Description : This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and isincorporated into a larger complex. This protein has nerve growth stimulating activity and the complex isinvolved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons.Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), anddysregulation of this gene"s expression is associated with allergic rhinitis.
Source : CHO cell
Species : Human
Tag : MIgG2a Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
Molecular Mass : 40KDa (monomer)
AA Sequence : Met1-Ala241
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : NGF nerve growth factor (beta polypeptide) [ Homo sapiens ]
Official Symbol : NGF
Synonyms : NGF; nerve growth factor (beta polypeptide); NGFB; beta-nerve growth factor; nerve growth factor, beta subunit; HSAN5; Beta-NGF; MGC161426; MGC161428;
Gene ID : 4803
mRNA Refseq : NM_002506
Protein Refseq : NP_002497
MIM : 162030
UniProt ID : P01138
Chromosome Location : 1p13.1
Pathway : ARMS-mediated activation, organism-specific biosystem; Activation of TRKA receptors, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Axonal growth stimulation, organism-specific biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Ceramide signalling, organism-specific biosystem;
Function : growth factor activity; nerve growth factor receptor binding; receptor signaling protein activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Is there a role for NGF protein in pain? 12/06/2022

Studies have shown that NGF protein plays a role in the occurrence and development of pain. It stimulates the growth and survival of sensory neurons and enhances their ability to transmit signals, thereby increasing pain sensation. In addition, NGF can interact with other pain-related molecules to modulate pain perception and tolerance.

How to use the activity of NGF protein for disease treatment? 05/21/2022

There are a variety of drug development treatments that target NGF proteins and their related signaling pathways, including direct administration of NGF proteins, use of their analogues, or drugs that inhibit its degradation. These treatments are in clinical trials and are expected to provide new options for the treatment of neurological disorders.

How does the NGF protein interact with target cells? 04/13/2022

NGF proteins interact with target cells by binding to their receptors. It binds to TrkA receptors on the surface of target cells, triggering a series of signal transduction mechanisms that ultimately influence the biological behavior of target cells.

What is the role of NGF proteins in other systems? 05/22/2021

In addition to its important role in the nervous system, NGF proteins can also affect the function of other systems. For example, NGF proteins can affect the function of the immune system, involved in inflammatory responses and the development of autoimmune diseases.

Which function of NGF protein in glial cells? 01/20/2021

The function of NGF protein in glial cells is mainly to regulate its proliferation, differentiation and apoptosis. In addition, NGF promotes the repair and regeneration of damaged neurons by glial cells.

What are the biological activities of NGF proteins? 01/11/2019

NGF proteins have a variety of biological activities, including promoting neuronal growth, differentiation, survival, and repair of damage, regulating connections and signaling between neurons, and influencing the function of other systems.

Customer Reviews (3)

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Reviews
06/29/2022

    High catalytic efficiency, high safety and high expression level of the protein make it perform well in many experiments.

    08/06/2020

      The short half-life and high clearance of NGF make it possible to better control the concentration and action time of drugs in the body, so as to better control the therapeutic effect.

      08/27/2019

        This production process of NGF pays attention to the recycling of resources and minimizes waste, which is very consistent with the principle of green production.

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