"TPO" Related Products

Expand

Recombinant Human Thyroid Peroxidase, MIgG2a Fc-tagged

Cat.No.: TPO-1334H
Product Overview: The extracellular domain of human TPO(AAC37566.1)(Ser22-Gly353) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.
Description: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
Source: CHO cell
Species: Human
Tag: MIgG2a Fc-tagged
Form: Lyophilized from 0.2 μm-filtered solution in PBS.
Bio-activity: Measured in a cell proliferation assay.
Molecular Mass: 62KDa (monomer)
AA Sequence: Ser22-Gly353
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100 μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: TPO thyroid peroxidase [ Homo sapiens ]
Official Symbol: TPO
Synonyms: TPO; thyroid peroxidase; TPX; thyroperoxidase; thyroid microsomal antigen; MSA; TDH2A;
Gene ID: 7173
mRNA Refseq: NM_000547
Protein Refseq: NP_000538
MIM: 606765
UniProt ID: P07202
Chromosome Location: 2p25
Pathway: Amine-derived hormones, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem;
Function: calcium ion binding; heme binding; iodide peroxidase activity; oxidoreductase activity; peroxidase activity;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.