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Recombinant Human CCL28, HIgG1 Fc-tagged, mutant

Cat.No.: CCL28-147H
Product Overview: The extracellular domain of human CCL28 (AAH69532.1)(Ile23-Tyr127) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell.
Description: This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs.
Source: CHO cell
Species: Human
Tag: HIgG1 Fc-tagged, mutant
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its ability to chemoattract BaF3 mouse pro-B cells.
Molecular Mass: 38KDa (monomer)
AA Sequence: Ile23-Tyr127
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: CCL28 chemokine (C-C motif) ligand 28 [ Homo sapiens ]
Official Symbol: CCL28
Synonyms: CCL28; chemokine (C-C motif) ligand 28; C-C motif chemokine 28; CC chemokine CCL28; CCK1; MEC; mucosae associated epithelial chemokine; SCYA28; small inducible cytokine A28; small inducible cytokine subfamily A (Cys Cys); member 28; small-inducible cytokine A28; mucosae-associated epithelial chemokine; chemokine (C-C motif) ligand 28 splice variant chi; small inducible cytokine subfamily A (Cys-Cys), member 28; MGC71902;
Gene ID: 56477
mRNA Refseq: NM_148672
Protein Refseq: NP_683513
MIM: 605240
UniProt ID: Q9NRJ3
Chromosome Location: 5p12
Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem;
Function: chemokine activity;

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