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Recombinant Human Chemokine (C-C motif) Ligand 22, HIgG1 Fc-tagged, mutant

Cat.No.: CCL22-3862H
Product Overview: The extracellular domain of human CCL22 (AAH27952.1)(Gly25-Gln93) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell.
Description: This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are afamily of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines areproteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activityfor monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It alsodisplays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils,eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokinemay play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects ofactivated T lymphocyte physiology.
Source: CHO cell
Species: Human
Tag: HIgG1 Fc-tagged, mutant
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by by a chemotaxis bioassay using human T-lymphocytes
Molecular Mass: 34 KDa (monomer)
AA Sequence: Gly25-Gln93
Endotoxin: <0.06 eu/μg as determined by lal>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: CCL22 chemokine (C-C motif) ligand 22 [ Homo sapiens ]
Official Symbol: CCL22
Synonyms: CCL22; chemokine (C-C motif) ligand 22; SCYA22, small inducible cytokine subfamily A (Cys Cys), member 22; C-C motif chemokine 22; A 152E5.1; ABCD 1; DC/B CK; MDC; MGC34554; STCP 1; MDC(1-69); CC chemokine STCP-1; macrophage-derived chemokine; small inducible cytokine A22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1; small inducible cytokine subfamily A (Cys-Cys), member 22; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1;
Gene ID: 6367
mRNA Refseq: NM_002990
Protein Refseq: NP_002981
MIM: 602957
UniProt ID: O00626
Chromosome Location: 16q13
Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; GPCR ligand binding, organism-specific biosystem;
Function: chemokine activity;

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