Active Recombinant Human Chemokine (C-C motif) Ligand 22, HIgG1 Fc-tagged, mutant

• Cat.No.: CCL22-3862H
• Product Overview: The extracellular domain of human CCL22 (AAH27952.1)(Gly25-Gln93) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell.

Specification

• Description: This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are afamily of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines areproteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activityfor monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It alsodisplays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils,eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokinemay play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects ofactivated T lymphocyte physiology.
• Source: CHO cell
• Species: Human
• Tag: HIgG1 Fc-tagged, mutant
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by by a chemotaxis bioassay using human T-lymphocytes
• Molecular Mass: 34 KDa (monomer)
• AA Sequence: Gly25-Gln93
• Endotoxin: <0.06 eu/μg as determined by lal>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: CCL22 chemokine (C-C motif) ligand 22 [ Homo sapiens ]
• Official Symbol: CCL22
• Synonyms: CCL22; chemokine (C-C motif) ligand 22; SCYA22, small inducible cytokine subfamily A (Cys Cys), member 22; C-C motif chemokine 22; A 152E5.1; ABCD 1; DC/B CK; MDC; MGC34554; STCP 1; MDC(1-69); CC chemokine STCP-1; macrophage-derived chemokine; small inducible cytokine A22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1; small inducible cytokine subfamily A (Cys-Cys), member 22; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1
• Gene ID: 6367
• mRNA Refseq: NM_002990
• Protein Refseq: NP_002981
• MIM: 602957
• UniProt ID: O00626
• Chromosome Location: 16q13
• Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; GPCR ligand binding, organism-specific biosystem
• Function: chemokine activity