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Recombinant Human Chemokine (C-C Motif) Ligand 7, HIgG1 Fc-tagged, mutant

Cat.No.: CCL7-384H
Product Overview: The extracellular domain of human CCL7 (AAI12259.1)(Gln24-Leu99) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell.
Description: This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q
Source: CHO cell
Species: Human
Tag: HIgG1 Fc-tagged, mutant
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its ability to chemoattract 2-day cultured human monocytes.
Molecular Mass: 35KDa (monomer)
AA Sequence: Gln24-Leu99
Endotoxin: <0.06 eu/μg as determined by lal>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: CCL7 chemokine (C-C motif) ligand 7 [ Homo sapiens ]
Official Symbol: CCL7
Synonyms: CCL7; chemokine (C-C motif) ligand 7; SCYA6, SCYA7, small inducible cytokine A7 (monocyte chemotactic protein 3); C-C motif chemokine 7; FIC; MARC; MCP 3; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; NC28; small-inducible cytokine A7; small inducible cytokine A7 (monocyte chemotactic protein 3); MCP-3; SCYA6; SCYA7; MGC138463; MGC138465;
Gene ID: 6354
mRNA Refseq: NM_006273
Protein Refseq: NP_006264
MIM: 158106
UniProt ID: P80098
Chromosome Location: 17q11.2-q12
Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; GPCR ligand binding, organism-specific biosystem;
Function: CCR1 chemokine receptor binding; chemokine activity; heparin binding;

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