Active Recombinant Mouse Interleukin 17A, MIgG2a Fc-tagged, mutant

• Cat.No.: IL17A-588M
• Product Overview: The extracellular domain of mouse IL-17 (NP_034682.1)(Met1-Leu142) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a was expressed in CHO cell.

Specification

• Description: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokineregulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate theexpression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoidarthritis, psoriasis and multiple sclerosis.
• Source: CHO cell
• Species: Mouse
• Tag: MIgG2a Fc-tagged, mutant
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to induce IL-6 secretion .
• Molecular Mass: 39KDa (monomer)
• AA Sequence: Met1-Leu142
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Il17a interleukin 17A [ Mus musculus ]
• Official Symbol: IL17A
• Synonyms: IL17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; Il17; Ctla8; IL-17; Ctla-8; IL-17A
• Gene ID: 16171
• mRNA Refseq: NM_010552
• Protein Refseq: NP_034682
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem
• Function: cytokine activity