Active Recombinant Human Interleukin 17A, HIgG1 Fc-tagged, mutant
Cat.No. : | IL17A-571H |
Product Overview : | The extracellular domain of human IL-17 (AAH67505.1)(Ile20-Ala155) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis |
Source : | CHO cell |
Species : | Human |
Tag : | HIgG1 Fc-tagged, mutant |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its ability to induce IL-6 secretion. |
Molecular Mass : | 42KDa (monomer) |
AA Sequence : | Ile20-Ala155 |
Endotoxin : | <0.06 eu/μg as determined by lal>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | IL17A interleukin 17A [ Homo sapiens ] |
Official Symbol : | IL17A |
Synonyms : | IL17A; interleukin 17A; CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); interleukin-17A; cytotoxic T lymphocyte associated protein 8; IL 17; IL 17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); IL17; CTLA8; IL-17; IL-17A; |
Gene ID : | 3605 |
mRNA Refseq : | NM_002190 |
Protein Refseq : | NP_002181 |
MIM : | 603149 |
UniProt ID : | Q16552 |
Chromosome Location : | 6p12 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; IL27-mediated signaling events, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem; |
Function : | cytokine activity; |
Products Types
◆ Recombinant Protein | ||
IL17A-141R | Recombinant Rat IL17A Protein | +Inquiry |
IL17A-15P | Recombinant Pig IL17A Protein (Gly26-Ser155), C-His tagged, Animal-free, Carrier-free | +Inquiry |
IL17A-441R | Active Recombinant Rabbit IL17 Protein, His-tagged | +Inquiry |
IL17A-148H | Recombinant Active Human IL17A Protein, His-tagged(C-ter) | +Inquiry |
IL17A-140M | Recombinant Mouse IL-17AF Heterodimer Protein | +Inquiry |
◆ Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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