Active Recombinant Human IL10RB, HIgG1 Fc-tagged
Cat.No. : | IL10RB-202H |
Product Overview : | The extracellular domain of human IL-10RB (AAH01903.1) (Met20-Ser220) is fused to the N-terminus of the Fc region of a human IgG1 was expressed in CHO cell. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21 |
Source : | CHO cell |
Species : | Human |
Tag : | HIgG1 Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its binding ability in a functional ELISA. |
Molecular Mass : | 50KDa (monomer) |
AA Sequence : | Met20-Ser220 |
Endotoxin : | <0.06 eu/μg as determined by lal>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | IL10RB interleukin 10 receptor, beta [ Homo sapiens ] |
Official Symbol : | IL10RB |
Synonyms : | IL10RB; interleukin 10 receptor, beta; CRFB4, D21S58, D21S66; interleukin-10 receptor subunit beta; CDW210B; CRF2 4; IL 10R2; IL-10RB; IL-10R subunit 2; IL-10R subunit beta; IL-10 receptor subunit beta; cytokine receptor class-II CRF2-4; interleukin-10 receptor subunit 2; cytokine receptor class-II member 4; cytokine receptor family 2 member 4; cytokine receptor family II, member 4; CRFB4; CRF2-4; D21S58; D21S66; IL-10R2; |
Gene ID : | 3588 |
mRNA Refseq : | NM_000628 |
Protein Refseq : | NP_000619 |
MIM : | 123889 |
UniProt ID : | Q08334 |
Chromosome Location : | 21q22.11 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; Toxoplasmosis, organism-specific biosystem; Toxoplasmosis, conserved biosystem; Tuberculosis, organism-specific biosystem; |
Function : | contributes_to interleukin-10 receptor activity; protein binding; receptor activity; |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (10)
Ask a questionMass spectrometry-based interactomics identifies proteins interacting with IL10RB.
NMR spectroscopy helps understand dynamic interactions and structural shifts in IL10RB upon binding.
Proximity labeling and quantitative proteomics show IL10RB's changing protein network with IL-10.
Techniques like surface plasmon resonance and isothermal titration calorimetry measure IL10RB-IL-10 binding strength and kinetics.
Flow cytometry and single-cell transcriptomics reveal IL10RB's expression diversity in cells and immune subsets.
Mutagenesis and alanine scanning pinpoint amino acids essential for IL10RB's binding to IL-10.
CRISPR-edited cells and knockout models explore IL10RB's signaling after IL-10 binding.
X-ray crystallography and cryo-electron microscopy provide structural insights into IL10RB's changes upon IL-10 interaction.
Genome-wide CRISPR screening uncovers genes affecting IL10RB expression and function.
Co-immunoprecipitation and FRET study protein complexes involving IL10RB and IL-10.
Customer Reviews (3)
Write a reviewReliable in co-immunoprecipitation.
High specificity.
Effective in signaling pathways.
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