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Active Recombinant Rat Interleukin 4, HIgG1 Fc-tagged

Cat.No. : IL4-458R
Product Overview : The extracellular domain of rat IL-4(NP_000580)(Met1-Ser153) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
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Description : The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is aligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to manyoverlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, hasbeen shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3,IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13.This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in anover 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encodingdistinct isoforms have been reported.
Source : CHO cell
Species : Rat
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
Molecular Mass : 43 KDa (monomer)
AA Sequence : Met1-Ser153
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : Il4 interleukin 4 [ Rattus norvegicus ]
Official Symbol : IL4
Synonyms : IL4; interleukin 4; interleukin-4; IL-4; BSF-1; B-cell growth factor 1; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1; B-cell IGG differentiation factor; Il4e12;
Gene ID : 287287
mRNA Refseq : NM_201270
Protein Refseq : NP_958427
Pathway : Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;
Function : cytokine activity; cytokine activity; growth factor activity; interleukin-4 receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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10/17/2021

    By testing immunogenicity in animal models, detect whether an immune response is induced.

    11/09/2020

      The structure of the recombinant protein was analyzed by nuclear magnetic resonance (NMR), X-ray crystallography or electron microscopy, and the results showed that the protein was stable.

      05/06/2020

        This protein has good stability, and the test results of heat resistance, acid and alkali resistance and protease degradation resistance are good.

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