"TNFRSF11B" Related Products

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Recombinant Human tumor necrosis factor receptor superfamily, member 11b, HIgG1 Fc-tagged

Cat.No.: TNFRSF11B-152H
Product Overview: The extracellular domain of human OPG (AAH30155.1) (Glu22-Leu401) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell.
Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Source: CHO cells
Species: Human
Tag: HIgG1 Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its ability to inhibit TRAIL-mediated cytotoxicity.
Molecular Mass: 70KDa (monomer)
AA Sequence: Glu22-Leu401
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: TNFRSF11B tumor necrosis factor receptor superfamily, member 11b [ Homo sapiens ]
Official Symbol: TNFRSF11B
Synonyms: TNFRSF11B; tumor necrosis factor receptor superfamily, member 11b; OPG, osteoprotegerin; tumor necrosis factor receptor superfamily member 11B; OCIF; TR1; osteoprotegerin; osteoclastogenesis inhibitory factor; OPG; MGC29565;
Gene ID: 4982
mRNA Refseq: NM_002546
Protein Refseq: NP_002537
MIM: 602643
UniProt ID: O00300
Chromosome Location: 8q24
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Monoamine Transport, organism-specific biosystem; Osteoblast Signaling, organism-specific biosystem; Osteoclast Signaling, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem;
Function: binding; cytokine activity; receptor activity;

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