"CCL11" Related Products

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Recombinant Human CCL11, HIgG1 Fc-tagged

Cat.No.: CCL11-167H
Product Overview: The extracellular domain of human CCL11 (NP_002977.1)(Gly24-Pro97) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell
Description: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
Source: CHO cells
Species: Human
Tag: HIgG1 Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its ability to chemoattract BaF3 mouse pro-B cells.
Molecular Mass: 34KDa (monomer)
AA Sequence: Gly24-Pro97
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: CCL11 chemokine (C-C motif) ligand 11 [ Homo sapiens ]
Official Symbol: CCL11
Synonyms: CCL11; chemokine (C-C motif) ligand 11; SCYA11, small inducible cytokine subfamily A (Cys Cys), member 11 (eotaxin); eotaxin; eotaxin 1; MGC22554; eotaxin-1; C-C motif chemokine 11; small-inducible cytokine A11; eosinophil chemotactic protein; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); SCYA11;
Gene ID: 6356
mRNA Refseq: NM_002986
Protein Refseq: NP_002977
MIM: 601156
UniProt ID: P51671
Chromosome Location: 17q21.1-q21.2
Pathway: Asthma, organism-specific biosystem; Asthma, conserved biosystem; CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem;
Function: chemokine activity;

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