Active Recombinant Human IL1R2, HIgG1 Fc-tagged
Cat.No. : | IL1R2-121H |
Product Overview : | The extracellular domain of human IL-1R2 (AAH39031.1)(Phe14-Glu343) is fused to the N-terminus of the Fc region of a human IgG1was expressed in CHO cell |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. |
Source : | CHO cells |
Species : | Human |
Tag : | HIgG1 Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its ability to inhibit IL-1 beta-dependent proliferation. |
Molecular Mass : | 64KDa (monomer) |
AA Sequence : | Phe14-Glu343 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | IL1R2 interleukin 1 receptor, type II [ Homo sapiens ] |
Official Symbol : | IL1R2 |
Synonyms : | IL1R2; interleukin 1 receptor, type II; IL1RB; interleukin-1 receptor type 2; CD121b; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2; IL-1R-beta; antigen CDw121b; IL-1 type II receptor; interleukin-1 receptor beta; interleukin-1 receptor type II; CD121 antigen-like family member B; type II interleukin-1 receptor, beta; MGC47725; |
Gene ID : | 7850 |
mRNA Refseq : | NM_004633 |
Protein Refseq : | NP_004624 |
MIM : | 147811 |
UniProt ID : | P27930 |
Chromosome Location : | 2q12 |
Pathway : | Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; |
Function : | interleukin-1 receptor activity; interleukin-1, Type II, blocking receptor activity; protein binding; receptor activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe intracellular domain of IL1R2 has functional significance; engineered constructs clarify its role.
Glycosylation of IL1R2 affects its IL-1 ligand interaction, and glycoproteomics methods can reveal critical glycosylation sites.
Engineered IL1R2 variants offer insights into its mechanisms and therapeutic potential.
IL1R2's presence impacts IL-1 ligand signaling through competition with IL1R1; genetic manipulations unveil this interaction.
Post-translational modifications, including ubiquitination, influence IL1R2's stability.
IL1R2 expression responds to inflammation; transcription factors play a role in its regulation.
Super-resolution microscopy helps understand IL1R2's trafficking and subcellular dynamics in detail.
Specific structural elements of IL1R2 contribute to its decoy role; X-ray crystallography provides insights into ligand binding.
Ectodomain shedding contributes to IL1R2's soluble decoy role; specific enzymes are involved.
IL1R2's interaction with accessory proteins is significant for its decoy function.
Customer Reviews (3)
Write a reviewHigh specificity.
Good for flow cytometry.
Suitable for co-immunoprecipitation.
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