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Active Recombinant Human VSIG4, HIgG1 Fc-tagged

Cat.No. : VSIG4-511H
Product Overview : The extracellular domain of human VSIG4(AAH10525.1) (Arg20-Pro283) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell
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Description : This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants.
Source : CHO cell
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA.
AA Sequence : Arg20-Pro283
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : VSIG4 V-set and immunoglobulin domain containing 4 [ Homo sapiens ]
Official Symbol : VSIG4
Synonyms : VSIG4; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; Z39IG; protein Z39Ig; Ig superfamily protein; complement receptor of the immunoglobulin superfamily; CRIg;
Gene ID : 11326
mRNA Refseq : NM_001100431
Protein Refseq : NP_001093901
MIM : 300353
UniProt ID : Q9Y279
Chromosome Location : Xq12-q13.3
Function : protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the relationship of VSIG4 to other genes or proteins? 08/18/2022

VSIG4 has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

How can the disease be treated by regulating the levels of VSIG4? 05/09/2022

There are no drugs that directly regulate VSIG4 levels, but they can affect VSIG4 expression and function by modulating the immune system.

How to detect and analyze mutations in VSIG4? 02/08/2022

Mutations in VSIG4 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

What is the specific role of VSIG4 in tumor immunity? 12/17/2020

VSIG4 plays an important role in tumor immunity, which can inhibit the activation and function of T cells and NK cells, thereby promoting tumor growth and metastasis.

How to study the regulatory mechanism of VSIG4? 06/05/2020

Studying the regulatory mechanism of VSIG4 requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What are the mutation types of VSIG4? 05/08/2020

The types of mutations in VSIG4 include point mutations, insertions/deletions, duplications, etc., which can cause structural and functional abnormalities of the protein.

Customer Reviews (3)

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Reviews
11/08/2021

    Stable performance, excellent performance in a variety of experiments.

    10/01/2021

      No side effects, high safety.

      03/13/2021

        It has good antigenicity and can induce target immune response.

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