Active Recombinant Human SEMA5A, HIgG1 Fc-tagged
Cat.No. : | SMA5A-3512H |
Product Overview : | The extracellular domain of human SEMA5A (AAI15697.1) (Glu23-Thr765) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell |
- Specification
- Gene Information
- Related Products
Description : | This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain andseveral thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neuraldevelopment. This gene has been implicated as an autism susceptibility gene |
Source : | CHO cell |
Species : | Human |
Tag : | HIgG1 Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its ability to inhibit proliferation. |
Molecular Mass : | 110KDa (monomer) |
AA Sequence : | Glu23-Thr765 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [ Homo sapiens ] |
Official Symbol : | SEMA5A |
Synonyms : | SEMA5A; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; SEMAF; semaphorin-5A; semF; sema F; semaphorin F; semaphorin-F; FLJ12815; |
Gene ID : | 9037 |
mRNA Refseq : | NM_003966 |
Protein Refseq : | NP_003957 |
MIM : | 609297 |
UniProt ID : | Q13591 |
Chromosome Location : | 5p15.2 |
Pathway : | Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Other semaphorin interactions, organism-specific biosystem; Semaphorin interactions, organism-specific biosystem; |
Function : | axon guidance receptor activity; receptor activity; |
Products Types
◆ Recombinant Protein | ||
Sema5a-5762M | Recombinant Mouse Sema5a Protein, Myc/DDK-tagged | +Inquiry |
SEMA5A-1969H | Recombinant Human SEMA5A Protein, His (Fc)-Avi-tagged | +Inquiry |
Sema5a-8692M | Recombinant Mouse Sema5a protein(Met1-Thr765), His-tagged | +Inquiry |
SEMA5A-3952R | Recombinant Rhesus Macaque SEMA5A Protein, His (Fc)-Avi-tagged | +Inquiry |
SEMA5A-603H | Recombinant Human SEMA5A Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
SEMA5A-1860HCL | Recombinant Human SEMA5A cell lysate | +Inquiry |
SEMA5A-1310MCL | Recombinant Mouse SEMA5A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionSemaphorin-5A (SEMA5A) functions in cellular processes, primarily playing a role in neural development and axon guidance.
SEMA5A is predominantly localized in growth cones and axonal pathways within the nervous system.
There are potential therapeutic implications related to SEMA5A in neurological disorders involving neural development, making it a target for drug development.
SEMA5A participates in axon guidance and neuronal migration during neural development by interacting with Plexin-A and Neuropilin-1 receptors.
Specific receptors or co-receptors that SEMA5A interacts with include Plexin-A and Neuropilin-1, influencing its role in neural circuit formation.
SEMA5A contributes to the regulation of synaptic connectivity and plasticity in the nervous system, impacting neural circuit formation.
Dysregulation or abnormal expression of SEMA5A is associated with conditions such as autism spectrum disorders and developmental disorders.
Customer Reviews (3)
Write a reviewThe product's consistent outcomes fortified the reproducibility of our scientific inquiries.
Despite its cost, the product's contributions to our research goals made it an invaluable asset.
We appreciated the product's efficiency in achieving target protein upregulation with minimal time investment.
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