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Active Recombinant Human SEMA5A, HIgG1 Fc-tagged

Cat.No. : SMA5A-3512H
Product Overview : The extracellular domain of human SEMA5A (AAI15697.1) (Glu23-Thr765) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell
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Description : This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain andseveral thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neuraldevelopment. This gene has been implicated as an autism susceptibility gene
Source : CHO cell
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit proliferation.
Molecular Mass : 110KDa (monomer)
AA Sequence : Glu23-Thr765
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [ Homo sapiens ]
Official Symbol : SEMA5A
Synonyms : SEMA5A; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; SEMAF; semaphorin-5A; semF; sema F; semaphorin F; semaphorin-F; FLJ12815;
Gene ID : 9037
mRNA Refseq : NM_003966
Protein Refseq : NP_003957
MIM : 609297
UniProt ID : Q13591
Chromosome Location : 5p15.2
Pathway : Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Other semaphorin interactions, organism-specific biosystem; Semaphorin interactions, organism-specific biosystem;
Function : axon guidance receptor activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary function of Semaphorin-5A (SEMA5A) in cellular processes and neural development? 06/10/2021

Semaphorin-5A (SEMA5A) functions in cellular processes, primarily playing a role in neural development and axon guidance.

In which cellular compartments is SEMA5A predominantly localized, especially within the nervous system? 11/27/2019

SEMA5A is predominantly localized in growth cones and axonal pathways within the nervous system.

Are there therapeutic implications or potential targets related to SEMA5A in neurological disorders involving neural development? 08/10/2018

There are potential therapeutic implications related to SEMA5A in neurological disorders involving neural development, making it a target for drug development.

How does SEMA5A participate in axon guidance and neuronal migration during neural development? 05/25/2018

SEMA5A participates in axon guidance and neuronal migration during neural development by interacting with Plexin-A and Neuropilin-1 receptors.

Are there specific receptors or co-receptors that SEMA5A interacts with, influencing its role in neural circuit formation? 02/27/2018

Specific receptors or co-receptors that SEMA5A interacts with include Plexin-A and Neuropilin-1, influencing its role in neural circuit formation.

How does SEMA5A contribute to the regulation of synaptic connectivity and plasticity in the nervous system? 09/05/2016

SEMA5A contributes to the regulation of synaptic connectivity and plasticity in the nervous system, impacting neural circuit formation.

What diseases or conditions are associated with dysregulation or abnormal expression of SEMA5A? 05/11/2016

Dysregulation or abnormal expression of SEMA5A is associated with conditions such as autism spectrum disorders and developmental disorders.

Customer Reviews (3)

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Reviews
11/15/2022

    The product's consistent outcomes fortified the reproducibility of our scientific inquiries.

    03/26/2021

      Despite its cost, the product's contributions to our research goals made it an invaluable asset.

      03/09/2019

        We appreciated the product's efficiency in achieving target protein upregulation with minimal time investment.

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