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Recombinant Human VTCN1, HIgG1 Fc-tagged

Cat.No.: VTCN1-530H
Product Overview: The extracellular domain of human B7-H4(NP_078902.2)(Phe29-Ala258) is fused to the N-terminus of the Fc region of human IgG1was expressed in CHO cell
Description: This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene
Source: CHO cells
Species: Human
Tag: HIgG1 Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by the ablility to inhibit anti-CD3-induced proliferation of stimulated human T cells. Human T lymphocytes cultured for 72 hours with PHA were incubated for an additional 3 days in 96 well place coated with 500 ng/ml anti-CD3 and 10 ug/ml human B
Molecular Mass: 55 KDa (monomer)
AA Sequence: Phe29-Ala258
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: VTCN1 V-set domain containing T cell activation inhibitor 1 [ Homo sapiens ]
Official Symbol: VTCN1
Synonyms: VTCN1; V-set domain containing T cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; B7 family member; H4; B7 superfamily member 1; B7 H4; B7H4; B7S1; B7X; FLJ22418; B7 family member, H4; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; immune costimulatory protein B7-H4; B7-H4; B7h.5; VCTN1; PRO1291; RP11-229A19.4;
Gene ID: 79679
mRNA Refseq: NM_001253849
Protein Refseq: NP_001240778
MIM: 608162
UniProt ID: Q7Z7D3
Chromosome Location: 1p12
Function: receptor binding;

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