Active Recombinant Human IL21, MIgG2a Fc-tagged
| Cat.No. : | IL21-004H |
| Product Overview : | The extracellular domain of human IL-21 (NP_068575.1) (Gln32-Ser162) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO celL |
- Specification
- Gene Information
- Related Products
| Description : | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Source : | CHO cells |
| Species : | Human |
| Tag : | MIgG2a Fc-tagged |
| Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Bio-activity : | Measured in a cell proliferation assay using N1186 human T cells. |
| Molecular Mass : | 44 KDa (monomer) |
| AA Sequence : | Gln32-Ser162 |
| Endotoxin : | <0.06 eu/μg as determined by lal> |
| Purity : | >98%, by SDS-PAGE under reducing conditions. |
| Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Warning : | Avoid freeze/thaw cycles. |
| Gene Name : | IL21 interleukin 21 [ Homo sapiens ] |
| Official Symbol : | IL21 |
| Synonyms : | IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21; |
| Gene ID : | 59067 |
| mRNA Refseq : | NM_001207006 |
| Protein Refseq : | NP_001193935 |
| MIM : | 605384 |
| UniProt ID : | Q9HBE4 |
| Chromosome Location : | 4q26-q27 |
| Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; |
| Function : | cytokine activity; cytokine receptor binding; interleukin-2 receptor binding; |
Products Types
| ◆ Lysates | ||
| IL21-001RCL | Recombinant Rat IL21 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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