"IL21" Related Products

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Recombinant Human IL21, MIgG2a Fc-tagged

Cat.No.: IL21-004H
Product Overview: The extracellular domain of human IL-21 (NP_068575.1) (Gln32-Ser162) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO celL
Description: This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Source: CHO cells
Species: Human
Tag: MIgG2a Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured in a cell proliferation assay using N1186 human T cells.
Molecular Mass: 44 KDa (monomer)
AA Sequence: Gln32-Ser162
Endotoxin: <0.06 eu/μg as determined by lal>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: IL21 interleukin 21 [ Homo sapiens ]
Official Symbol: IL21
Synonyms: IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21;
Gene ID: 59067
mRNA Refseq: NM_001207006
Protein Refseq: NP_001193935
MIM: 605384
UniProt ID: Q9HBE4
Chromosome Location: 4q26-q27
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function: cytokine activity; cytokine receptor binding; interleukin-2 receptor binding;

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