"DcR3" Related Products

Recombinant Human DcR3, HIgG1 Fc-tagged

Cat.No.: DcR3-678H
Product Overview: A soluble dimeric fusion protein consisting of the extracellular domain of human DcR3(O95407) (Val24-His300) was fused to human IgG1 Fc.
Description: This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript
Source: CHO cell
Species: Human
Tag: HIgG1 Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its ability to inhibit Fas Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells.
AA Sequence: A soluble dimeric fusion protein consisting of the extracellular domain of human DcR3(O95407) (Val24-His300) was fused to human IgG1 Fc.
Endotoxin: <0.06eu mu;g as determined by lal>
Purity: >98%(SDS-PAGE)
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy [ Homo sapiens (human) ]
Official Symbol: DcR3
Synonyms: TNFRSF6B; M68; TR6; DCR3; M68E; DJ583P15.1.1; tumor necrosis factor receptor superfamily, member 6b, decoy; tumor necrosis factor receptor superfamily member 6B; decoy receptor 3; decoy receptor for Fas ligand
Gene ID: 8771
mRNA Refseq: NM_003823
Protein Refseq: NP_003814
MIM: 603361
UniProt ID: O95407
Chromosome Location: 20q13.3
Pathway: Apoptosis Modulation and Signaling; Cytokine-cytokine receptor interaction; Cytosolic Iron-sulfur Cluster Assembly
Function: protein binding; receptor activity

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