Active Recombinant Mouse VTCN1, MIgG2a Fc-tagged

• Cat.No.: VTCN1-533H
• Product Overview: The extracellular domain of mouse B7-H4(NP_848709.2)(Phe29-Pro258) is fused to the N-terminus of the Fc region of mouse IgG2a.

Specification

• Description: This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene
• Source: CHO cells
• Species: Mouse
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
• Molecular Mass: 54 KDa (monomer)
• AA Sequence: Phe29-Pro258
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: ≥98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Vtcn1 V-set domain containing T cell activation inhibitor 1 [ Mus musculus ]
• Official Symbol: VTCN1
• Synonyms: VTCN1; V-set domain containing T cell activation inhibitor 1; V-set domain containing T-cell activation inhibitor 1; t cell costimulatory molecule B7x; immune costimulatory protein B7-H4; B7x; B7h4; B7s1; BC032925; MGC41287
• Gene ID: 242122
• mRNA Refseq: NM_178594
• Protein Refseq: NP_848709
• Function: receptor binding