Active Recombinant Human KITLG, HIgG1 Fc-tagged, mutant

• Cat.No.: KITLG-21H
• Product Overview: The extracellular domain of human SCF (NP_003985.2) (aa 26-187) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell.

Specification

• Description: This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is apleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believedto reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for itscontinued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found forthis gene.
• Source: CHO cells
• Species: Human
• Tag: HIgG1 Fc-tagged, mutant
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
• Molecular Mass: 47 KDa (monomer)
• AA Sequence: The extracellular domain of human SCF (NP_003985.2) (aa 26-187) is fused to the N-terminus of the Fc region of a mutant human IgG1.
• Endotoxin: <0.06 eu/μg as determined by lal>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: KITLG KIT ligand [ Homo sapiens ]
• Official Symbol: KITLG
• Synonyms: KITLG; KIT ligand; MGF; kit ligand; familial progressive hyperpigmentation 2; FPH2; Kitl; KL 1; mast cell growth factor; SCF; SF; steel factor; stem cell factor; c-Kit ligand; KL-1; SHEP7; kit-ligand; DKFZp686F2250
• Gene ID: 4254
• mRNA Refseq: NM_000899
• Protein Refseq: NP_000890
• MIM: 184745
• UniProt ID: P21583
• Chromosome Location: 12q22
• Pathway: C-MYB transcription factor network, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Kit Receptor Signaling Pathway, organism-specific biosystem; Melanogenesis, organism-specific biosystem
• Function: cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding