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Recombinant Human KITLG, HIgG1 Fc-tagged, mutant

Cat.No.: KITLG-21H
Product Overview: The extracellular domain of human SCF (NP_003985.2) (aa 26-187) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell.
Description: This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is apleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believedto reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for itscontinued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found forthis gene.
Source: CHO cells
Species: Human
Tag: HIgG1 Fc-tagged, mutant
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
Molecular Mass: 47 KDa (monomer)
AA Sequence: The extracellular domain of human SCF (NP_003985.2) (aa 26-187) is fused to the N-terminus of the Fc region of a mutant human IgG1.
Endotoxin: <0.06 eu/μg as determined by lal>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: KITLG KIT ligand [ Homo sapiens ]
Official Symbol: KITLG
Synonyms: KITLG; KIT ligand; MGF; kit ligand; familial progressive hyperpigmentation 2; FPH2; Kitl; KL 1; mast cell growth factor; SCF; SF; steel factor; stem cell factor; c-Kit ligand; KL-1; SHEP7; kit-ligand; DKFZp686F2250;
Gene ID: 4254
mRNA Refseq: NM_000899
Protein Refseq: NP_000890
MIM: 184745
UniProt ID: P21583
Chromosome Location: 12q22
Pathway: C-MYB transcription factor network, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Kit Receptor Signaling Pathway, organism-specific biosystem; Melanogenesis, organism-specific biosystem;
Function: cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding;

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